采用紫外分光光度法、气相色谱/氢火焰离子化检测器法和气相色谱/质谱联用法测定尿液和血液中的甲喹酮及其代谢物。
Determination of methaqualone and its metabolites in urine and blood by UV, GC/FID and GC/MS.
作者信息
Liu F, Liu Y T, Feng C L, Luo Y
机构信息
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
出版信息
Yao Xue Xue Bao. 1994;29(8):610-6.
A systematic procedure for the determination of methaqualone and its metabolites in blood and urine by UV spectrophotometry, GC and GC/MS was developed. Urine and blood samples were from a suicidal patient who ingested 18 tablets of methaqualone. Both solid phase and liquid-liquid extractions were used in the extraction and clean-up of the samples. The total amount of methaqualone and its metabolites was measured by UV spectrophotometry. The amount of parent methaqualone was quantitated by GC/FID. Methaqualone and its 10 metabolites including two acetyl metabolites were found in urine and blood. This procedure is useful for monitoring drugs in emergency treatment.
开发了一种通过紫外分光光度法、气相色谱法和气相色谱/质谱法测定血液和尿液中安眠酮及其代谢物的系统程序。尿液和血液样本来自一名摄入18片安眠酮的自杀患者。在样本的提取和净化过程中，同时使用了固相萃取和液液萃取。通过紫外分光光度法测定安眠酮及其代谢物的总量。母体安眠酮的含量通过气相色谱/氢火焰离子化检测器进行定量。在尿液和血液中发现了安眠酮及其10种代谢物，包括两种乙酰化代谢物。该程序有助于在紧急治疗中监测药物。
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