鲍曼不动杆菌GC1克隆群1型广泛耐药亚系的进化
Evolution of an extensively antibiotic resistant sublineage of lineage 1 of GC1 Acinetobacter baumannii.
作者信息
Harmer Christopher J, Luo Ting L, Lebreton Francois, McGann Patrick T, Hall Ruth M
机构信息
School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.
Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Bacterial Diseases Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
出版信息
NPJ Antimicrob Resist. 2025 May 9;3(1):36. doi: 10.1038/s44259-025-00103-5.
The multiply antibiotic-resistant lineage 1 of Acinetobacter baumannii global clone 1 (GC1) emerged in the 1970s, and subsequently more extensively resistant sublineages have emerged. Here, we examined the evolution of the extensively resistant MRSN56 sublineage and showed it is characterised by insertions carrying resistance genes at specific chromosomal positions. An evolved form of the sublineage carries KL17 replacing KL1 at the capsule locus and includes an additional integrative element Aci-IE1 carrying further resistance genes including bla. Further members of the modified sublineage (isolated 2014-2021) identified among publicly available genomes were from several countries and appear to have replaced the original form (2007-2010). Some KL17 type isolates had acquired even more resistance genes including bla. The bla and bla genes contribute to reduced susceptibility to cefiderocol and/or sulbactam/durlobactam. The phylogeny indicated that separation of the sublineage into KL1 and KL17 groups coincided with the KL switch and Aci-IE1 was acquired later.
鲍曼不动杆菌全球克隆1（GC1）的多重耐药谱系1于20世纪70年代出现，随后出现了耐药性更强的亚谱系。在此，我们研究了广泛耐药的MRSN56亚谱系的进化，发现其特征是在特定染色体位置携带耐药基因的插入序列。该亚谱系的一种进化形式在荚膜位点携带KL17取代了KL1，并包含一个额外的携带包括bla在内的更多耐药基因的整合元件Aci-IE1。在公开可用基因组中鉴定出的该修饰亚谱系的其他成员（于2014年至2021年分离）来自几个国家，似乎已经取代了原始形式（2007年至2010年）。一些KL17型分离株获得了更多耐药基因，包括bla。bla和bla基因导致对头孢地尔和/或舒巴坦/度洛巴坦的敏感性降低。系统发育分析表明，该亚谱系分为KL1和KL17组与KL转换同时发生，而Aci-IE1是后来获得的。
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