Corbett D, Silva L R, Stellar J R
Physiol Behav. 1985 Jan;34(1):89-95. doi: 10.1016/0031-9384(85)90083-6.
Intracranial self-stimulation (ICSS) of the medial prefrontal cortex (MFC) is acquired gradually, taking 4 or more days to establish. One explanation for this finding is that the stimulation becomes more rewarding with repetition. Four experiments were conducted to test this hypotheses. In Experiment 1, the MFC ICSS frequency thresholds remained constant over the first 3 weeks of testing while the rate of lever pressing response increased. In Experiment 2, it was found that acquisition of MFC ICSS was much more rapid when a motorically simpler response (nose-poking) was employed. Similarly, Experiments 3 and 4 further demonstrated that response factors such as task complexity may ultimately determine the rate of development of frontal cortex ICSS. Overall, these data suggest that independent of the rewarding effects of MFC stimulation there are other effects that initially interfere with learning of complex operant responses.
内侧前额叶皮质（MFC）的颅内自我刺激（ICSS）是逐渐习得的，需要4天或更长时间才能建立。这一发现的一种解释是，随着重复，刺激变得更具奖赏性。进行了四项实验来检验这一假设。在实验1中，在测试的前三周，MFC的ICSS频率阈值保持不变，而杠杆按压反应的速率增加。在实验2中，发现当采用运动上更简单的反应（鼻触）时，MFC的ICSS习得要快得多。同样，实验3和实验4进一步证明，诸如任务复杂性等反应因素可能最终决定额叶皮质ICSS的发展速度。总体而言，这些数据表明，除了MFC刺激的奖赏效应之外，还有其他效应最初会干扰复杂操作性反应的学习。
