Alvarez E O, Guerra F A
Physiol Behav. 1982 Jun;28(6):1035-40. doi: 10.1016/0031-9384(82)90172-x.
Increasing evidence supports the concept that histamine would subserve neurotransmitter functions in the brain. In hippocampus, some cases of histamine receptors coupled to adenylate cyclase has been described. In our laboratory we were interested in studying the possible physiological role of these histamine receptors and behavior. Unilateral cannulae were stereotaxically implanted in the caudal hippocampus in adult male rats. Forty-eight hours later, after an acute microinjection of histamine (1 microgram), 3-methyl-histamine (1 microgram) or saline (1 microliter), the following behavioral parameters were measured by an observer in an open-field: locomotor, rearing, sniffing, grooming, social sniffing and holding activities. It was observed that histamine inhibited locomotor and rearing activities; whereas, 3-methyl-histamine induced an increase in almost all behaviors. Results support the concept of a probable function of histamine in exploratory behavior in the rat.
越来越多的证据支持组胺在大脑中发挥神经递质功能这一概念。在海马体中，已经描述了一些组胺受体与腺苷酸环化酶偶联的情况。在我们实验室，我们感兴趣于研究这些组胺受体可能的生理作用及其与行为的关系。将单侧套管通过立体定位法植入成年雄性大鼠的尾侧海马体中。48小时后，在急性微量注射组胺（1微克）、3 - 甲基组胺（1微克）或生理盐水（1微升）后，由一名观察者在旷场中测量以下行为参数：运动、竖毛、嗅探、梳理、社交嗅探和抱持活动。观察到组胺抑制运动和竖毛活动；而3 - 甲基组胺几乎使所有行为增加。结果支持组胺在大鼠探索行为中可能发挥作用这一概念。
