Woo Seung-Bin, Lee Chang-Young, Kim Chang-Hyun, Kwon Min-Yong, Kim Jae Hyun, Kim Sang Pyo, Kwon Sae Min
Department of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
Department of Pathology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
Brain Tumor Res Treat. 2025 Apr;13(2):53-57. doi: 10.14791/btrt.2024.0044.
We report a rare and diagnostically challenging case of a 39-year-old male patient who presented with symptoms of dizziness and headaches, without any focal neurological symptoms. Initial imaging studies suggested a germ cell tumor, and an endoscopic biopsy led to a preliminary diagnosis of a pineal parenchymal tumor of intermediate differentiation. However, histological evaluation following surgical resection revealed the final diagnosis to be an ectopic pituitary neuroendocrine tumor (PitNET), a condition that is exceedingly rare. Ectopic PitNETs are uncommon tumors that develop outside the normal anatomical location of the pituitary gland. Their atypical presentation often leads to misdiagnosis as other intracranial neoplasms. This case highlights the diagnostic challenges posed by ectopic PitNETs and contributes to the limited literature on this rare condition. It underscores the importance of maintaining a broad differential diagnosis in patients presenting with atypical intracranial neoplasms.
我们报告了一例罕见且诊断具有挑战性的病例，一名39岁男性患者出现头晕和头痛症状，但无任何局灶性神经症状。初步影像学检查提示生殖细胞瘤，内镜活检初步诊断为中等分化的松果体实质肿瘤。然而，手术切除后的组织学评估显示最终诊断为异位垂体神经内分泌肿瘤（PitNET），这种情况极为罕见。异位PitNET是在垂体正常解剖位置以外发生的罕见肿瘤。它们的非典型表现常导致误诊为其他颅内肿瘤。该病例突出了异位PitNET带来的诊断挑战，并为关于这种罕见疾病的有限文献增添了内容。它强调了对表现为非典型颅内肿瘤的患者进行广泛鉴别诊断的重要性。
