Department of Radiology, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
Department of Neurology, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
Pituitary. 2019 Aug;22(4):339-343. doi: 10.1007/s11102-019-00954-y.
Ectopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal pituitary migration. Clinically, these tumors vary in hormonal activity and can exert mass effect based on location and size.
We performed a single-center retrospective analysis of patients with diagnosis of ectopic pituitary adenoma from 2001 to 2018.
Five patients were identified with EPA: a 48-year-old woman with suprasellar EPA treated with transsphenoidal removal of the tumor, a 44-year-old woman with cavernous EPA treated with transsphenoidal removal of the tumor, a 48-year-old woman with sphenoid EPA treated with cabergoline, a 45-year-old man with clival EPA treated with cabergoline and transsphenoidal surgical resection, and a 54-year-old man with clival EPA treated with cabergoline therapy.
EPA should be considered as a differential diagnosis of juxta-sellar lesions. Appropriate hormonal testing may lead to early diagnosis, avoidance of unnecessary biopsy or surgery, and improved outcomes.
异位垂体腺瘤（Ectopic Pituitary Adenoma，EPA）是一种罕见的肿瘤，被认为起源于正常垂体迁移路径上的胚胎残余物。临床上，这些肿瘤的激素活性各异，并可根据位置和大小产生占位效应。
我们对 2001 年至 2018 年期间诊断为异位垂体腺瘤的患者进行了单中心回顾性分析。
共发现 5 例 EPA 患者：1 例 48 岁女性，蝶鞍上 EPA，经蝶窦切除术治疗；1 例 44 岁女性，海绵窦 EPA，经蝶窦切除术治疗；1 例 48 岁女性，蝶骨 EPA，采用卡麦角林治疗；1 例 45 岁男性，斜坡 EPA，采用卡麦角林和经蝶窦手术切除术治疗；1 例 54 岁男性，斜坡 EPA，采用卡麦角林治疗。
EPA 应被视为鞍旁病变的鉴别诊断。适当的激素检测可能有助于早期诊断，避免不必要的活检或手术，并改善预后。
