Ragmoun W, Massoudi H, Lajmi M, Ziadi M, Shenik M S
Department of Cardiothoracic Surgery, The Principal Military Hospital of Instruction of Tunis, Tunisia.
Department of Cardiothoracic Surgery, The Principal Military Hospital of Instruction of Tunis, Tunisia.
Int J Surg Case Rep. 2025 Jun;131:111365. doi: 10.1016/j.ijscr.2025.111365. Epub 2025 Apr 25.
Rheumatic multivalvular disease is typically associated with annular narrowing, especially of the aortic valve, and even more so when it is accompanied by mitral valve involvement.
A 60-year-old woman with a history of rheumatic mitral valve disease previously treated with open-heart mitral commissurotomy presented with NYHA class III dyspnea, progressively worsening over the past six months. Physical examination revealed a body mass index (BMI) of 25 and a body surface area (BSA) of 1.6 m. There were no signs of heart failure. The pulse was irregular, with a systolic murmur heard at the mitral area and a diastolic murmur at the aortic area. Transthoracic echocardiography revealed both mitral and aortic valve disease, predominantly regurgitant in nature, with significant retraction and calcification of the leaflets. Notably, there was annular narrowing, especially of the aortic annulus. These findings were associated with severe tricuspid regurgitation and marked dilation of the right heart chambers. Left ventricular function was preserved. The patient underwent surgery under cardiopulmonary bypass. Intraoperative inspection revealed thickened and retracted aortic cusps, along with a small aortic annulus that could not accommodate a No. 19 Hegar dilator. Therefore, an aortic annulus enlargement using the Manouguian technique was performed, along with mitral valve replacement and tricuspid annuloplasty. A No. 21 mechanical prosthesis was implanted in the aortic position to prevent patient-prosthesis mismatch, a No. 29 mechanical prosthesis was placed in the mitral position, and a No. 32 tricuspid ring was inserted. The postoperative course was uneventful, and the patient was discharged on postoperative day four.
The management of a small aortic root during aortic valve replacement (AVR) has been a subject of discussion in cardiac surgery for over three decades and remains controversial. Several techniques have been developed to enlarge a narrowed aortic root and prevent patient-prosthesis mismatch (PPM). The challenge of implanting an aortic prosthesis becomes even more pronounced in patients with concomitant mitral valve disease. In such cases, insertion of the aortic prosthesis following mitral valve replacement is often more difficult than in patients with a normal or enlarged aortic root. When performing double valve replacement (DVR), enlargement of the aortic annulus-or both the aortic and mitral annuli-may be required to facilitate prosthesis implantation. However, there are only a few reports in the literature addressing DVR in combination with aortic root enlargement. During AVR, surgeons aim to implant the largest possible prosthesis in order to optimize hemodynamic outcomes, reduce transvalvular gradients, promote left ventricular reverse remodelling, and minimize the risk of PPM. Nonetheless, implantation of an ideally sized prosthesis is often limited by the presence of a small aortic annulus. Various aortic root and annular enlargement techniques have therefore been described to address this challenge and avoid mismatch.
Aortic root enlargement in patients undergoing double valve replacement can be performed safely and facilitates the implantation of an appropriately sized mechanical or biological aortic valve prosthesis in patients with a small aortic annulus, thereby helping to avoid patient-prosthesis mismatch.
风湿性多瓣膜病通常伴有瓣环狭窄,尤其是主动脉瓣,当合并二尖瓣受累时更是如此。
一名60岁女性,有风湿性二尖瓣疾病病史,曾接受开心二尖瓣交界切开术治疗,现出现纽约心脏协会(NYHA)III级呼吸困难,在过去六个月中逐渐加重。体格检查显示体重指数(BMI)为25,体表面积(BSA)为1.6平方米。无心力衰竭体征。脉搏不规则,在二尖瓣区可闻及收缩期杂音,在主动脉区可闻及舒张期杂音。经胸超声心动图显示二尖瓣和主动脉瓣均有病变,主要为反流性质,瓣叶明显回缩和钙化。值得注意的是,存在瓣环狭窄,尤其是主动脉瓣环。这些发现与严重三尖瓣反流和右心腔明显扩张有关。左心室功能保留。患者在体外循环下接受手术。术中检查发现主动脉瓣叶增厚和回缩,同时主动脉瓣环较小,无法容纳19号黑加扩张器。因此,采用马努吉安技术进行主动脉瓣环扩大术,同时进行二尖瓣置换和三尖瓣环成形术。在主动脉位置植入21号机械瓣膜以防止人工瓣膜与患者不匹配,在二尖瓣位置植入29号机械瓣膜,插入32号三尖瓣环。术后过程顺利,患者于术后第四天出院。
在心脏外科领域,主动脉瓣置换术(AVR)中处理小主动脉根部一直是一个讨论了三十多年的话题,至今仍存在争议。已经开发了几种技术来扩大狭窄的主动脉根部并防止人工瓣膜与患者不匹配(PPM)。在合并二尖瓣疾病的患者中,植入主动脉人工瓣膜的挑战更加明显。在这种情况下,二尖瓣置换后植入主动脉人工瓣膜通常比主动脉根部正常或扩大的患者更困难。进行双瓣膜置换(DVR)时,可能需要扩大主动脉瓣环或同时扩大主动脉瓣环和二尖瓣瓣环以方便人工瓣膜植入。然而,文献中仅有少数关于DVR联合主动脉根部扩大的报道。在AVR期间,外科医生旨在植入尽可能大的人工瓣膜,以优化血流动力学结果,降低跨瓣压差,促进左心室逆向重构,并最小化PPM风险。尽管如此,植入理想尺寸的人工瓣膜往往受到小主动脉瓣环的限制。因此,已经描述了各种主动脉根部和瓣环扩大技术来应对这一挑战并避免不匹配。
接受双瓣膜置换的患者进行主动脉根部扩大术可以安全进行,并有助于在主动脉瓣环较小的患者中植入尺寸合适的机械或生物主动脉瓣人工瓣膜,从而有助于避免人工瓣膜与患者不匹配。