加速迈向功能糖蛋白质组学的步伐。
Accelerating the stride toward functional glycoproteomics.
作者信息
Veth Tim S, Riley Nicholas M
机构信息
Department of Chemistry, University of Washington, Seattle, WA, USA.
Department of Chemistry, University of Washington, Seattle, WA, USA.
出版信息
Trends Biochem Sci. 2025 Jul;50(7):550-552. doi: 10.1016/j.tibs.2025.04.002. Epub 2025 May 9.
Abstract
The heterogeneity of the glycoproteome and the challenges associated with quantifying its regulation in complex biological systems have hindered functional glycoproteomics. The deep quantitative glycoprofiling (DQGlyco) method recently developed by Potel, Burtscher, and Garrido-Rodriguez et al. significantly improves the glycoproteomic depth compared with existing methods, aiding our ability to interrogate the functional implications of glycoproteins.
摘要
糖蛋白质组的异质性以及在复杂生物系统中对其调控进行定量分析所面临的挑战阻碍了功能糖蛋白质组学的发展。Potel、Burtscher和Garrido-Rodriguez等人最近开发的深度定量糖谱分析（DQGlyco）方法与现有方法相比，显著提高了糖蛋白质组分析的深度，有助于我们探究糖蛋白的功能意义。
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