Neumeister K, Wässer S
Radiat Environ Biophys. 1985;24(3):227-37. doi: 10.1007/BF01209526.
In 1967 a prospective clinical study was started with the aim of providing optimum counselling for married couples who desire continuation of a pregnancy despite radiation exposure at an early stage as a result of X-ray diagnostics. Recommendations were devised as to whether an interruption of pregnancy should be applied for or not. These results were discussed repeatedly. Within the framework of the prospective study, embryological examinations were made in cases of interruption of pregnancy, and clinical and genetic examinations in cases of children who had been subject to radiation stress in utero. Up to July 1st 1984 nearly 200 cases of consultations have been or are being surveyed. The children were subjected to selected longterm examinations of up to 13 years. The results of cytogenetic, biochemical-genetic, clinical, and other examinations are considered and special characteristics of interesting cases are discussed. The conclusion was drawn that the recommendation to our patients to continue pregnancy in cases of exposure to radiation in utero below 0.1 Sv, was right. Furthermore the question arose of whether this dose limit could be increased. The study will be continued.
1967年启动了一项前瞻性临床研究，旨在为那些因X射线诊断在孕早期受到辐射照射却仍希望继续妊娠的已婚夫妇提供最佳咨询服务。针对是否应该申请终止妊娠制定了相关建议。这些结果被反复讨论。在前瞻性研究框架内，对终止妊娠的病例进行了胚胎学检查，对子宫内受到辐射压力的儿童进行了临床和遗传学检查。截至1984年7月1日，已对近200例咨询病例进行或正在进行调查。对这些儿童进行了长达13年的选定长期检查。对细胞遗传学、生化遗传学、临床及其他检查结果进行了考量，并讨论了有趣病例的特殊特征。得出的结论是，建议我们的患者在子宫内辐射暴露低于0.1 Sv的情况下继续妊娠是正确的。此外，还出现了这个剂量限制是否可以提高的问题。该研究将继续进行。
