Kitazawa Yu, Sakakura Kazuki, Uda Hiroshi, Kuroda Naoto, Ueda Riyo, Firestone Ethan, Lee Min-Hee, Jeong Jeong-Won, Sonoda Masaki, Osawa Shin-Ichiro, Ukishiro Kazushi, Ishida Makoto, Kakinuma Kazuo, Ota Shoko, Takayama Yutaro, Iijima Keiya, Kambara Toshimune, Endo Hidenori, Suzuki Kyoko, Nakasato Nobukazu, Iwasaki Masaki, Asano Eishi
Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurology and Stroke Medicine, Yokohama City University, Yokohama, Kanagawa 2360004, Japan.
Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki 3058575, Japan; Department of Neurosurgery, Rush University Medical Center, Chicago, IL 60612, USA.
Clin Neurophysiol. 2025 Jul;175:2010729. doi: 10.1016/j.clinph.2025.04.008. Epub 2025 Apr 21.
We visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions.
We investigated 40 Japanese-speaking patients with focal epilepsy and estimated connectivity measures using cortical high-gamma dynamics and MRI tractography.
Hearing a wh-interrogative at question onset enhanced inter-hemispheric functional connectivity, with left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by functional connectivity diminution with right-to-left callosal suppressive flows between dorsolateral prefrontal regions. Processing verbs associated with concrete objects or adverbs increased left intra-hemispheric connectivity, with bidirectional facilitatory flows through extensive white matter pathways. Questions beginning with what, compared to where, induced greater neural engagement in the left posterior inferior-frontal gyrus at question offset, linked to enhanced functional connectivity and bidirectional facilitatory flows to the temporal lobe neocortex via the arcuate fasciculus. During overt responses, inter-hemispheric functional connectivity was enhanced, with bidirectional callosal flows between Rolandic areas, and individuals with higher IQ scores exhibited less prolonged neural engagement in the left posterior middle frontal gyrus.
Visualization of directional neural interactions within white matter networks during overt naming is feasible.
Phrase order may influence network dynamics in listeners, even when presented with auditory descriptive questions conveying similar meanings.
我们观察了特定白质网络内的功能连接和有效连接，以回应听觉描述性问题。
我们对40名讲日语的局灶性癫痫患者进行了研究，并使用皮质高伽马动力学和磁共振成像纤维束成像来估计连接测量值。
在问题开始时听到以wh开头的疑问句会增强半球间功能连接，颞上回之间存在从左到右的胼胝体促进性流动，与之形成对比的是，背外侧前额叶区域之间从右到左的胼胝体抑制性流动会导致功能连接减弱。处理与具体物体或副词相关的动词会增加左半球内连接，通过广泛的白质通路实现双向促进性流动。与以where开头的问题相比，以what开头的问题在问题结束时会在左后下额叶回引起更大的神经参与，这与增强的功能连接以及通过弓状束向颞叶新皮质的双向促进性流动有关。在公开回答期间，半球间功能连接增强，中央前回区域之间存在双向胼胝体流动，智商得分较高的个体在左后中额叶回的神经参与持续时间较短。
在公开命名过程中可视化白质网络内的定向神经相互作用是可行的。
即使呈现传达相似含义的听觉描述性问题，短语顺序也可能影响听众的网络动态。
