Effmann E L, Merten D F, Kirks D R, Pratt P C, Spock A
Radiology. 1985 Oct;157(1):69-74. doi: 10.1148/radiology.157.1.4034980.
Clinical, radiological, and pathologic data for nine children with adult respiratory distress syndrome (ARDS) were reviewed. The children ranged in age from 7 months to 15 years (mean age, 7.4 yrs). Underlying diseases and precipitating events included sepsis, pneumonia, near drowning, aspiration pneumonia, central nervous system trauma, and malignancy. All patients had the rapid onset of diffuse bilateral lung opacification, required assisted ventilation for periods of 5-86 days (mean, 25.2 days), and received high levels of inspired oxygen for 2-41 days (mean, 12.7 days). Eight patients manifested air leak complications; these problems persisted until the patients died or were weaned from the respirator. Five of the nine patients died. Autopsy in three patients demonstrated alveolar duct fibrosis characteristic of the late proliferative phase of ARDS and consistent with oxygen toxicity. Two survivors demonstrated mild restrictive changes on follow-up pulmonary function tests and showed persistent linear densities on chest radiographs.
回顾了9例成人呼吸窘迫综合征（ARDS）患儿的临床、放射学和病理学资料。患儿年龄从7个月至15岁不等（平均年龄7.4岁）。基础疾病和诱发因素包括败血症、肺炎、近乎溺水、吸入性肺炎、中枢神经系统创伤和恶性肿瘤。所有患者均迅速出现双侧肺部弥漫性混浊，需要5 - 86天（平均25.2天）的辅助通气，并接受2 - 41天（平均12.7天）的高浓度吸氧。8例患者出现了气漏并发症；这些问题一直持续到患者死亡或脱机。9例患者中有5例死亡。3例患者的尸检显示出ARDS晚期增殖期特征性的肺泡管纤维化，与氧中毒相符。2例幸存者在随访肺功能测试中表现出轻度限制性改变，胸部X线片上显示持续的线状致密影。
