Xu Zhen, Bao Lulu, Wang Xiaomin, Ying Haihang, Mao Jianbo
Yongkang Hospital, Jinhua, Zhejiang, China.
Zhejiang Provincial People's Hospital, Hangzhou, 31000, Zhejiang, China.
BMC Ophthalmol. 2025 May 12;25(1):285. doi: 10.1186/s12886-025-04086-9.
To explore the factors causing structural abnormalities of meibomian gland in the pediatric population.
Two-hundred children were enrolled to evaluate the morphology of meibomian gland. Demographic and clinical information were collected. Symptoms of dry eye disease (DED) were assessed with the ocular surface disease index (OSDI) questionnaire. Meibography was performed and grading of images was performed by a 5-point meiboscale (0-4) for gland atrophy and a 3-point score (0-2) for gland tortuosity.
200 eyes of 200 participants aged 10-18 years (13.10 ± 2.39 years) were imaged. Most patients had a score of 1, 130 (65%) in meiboscore and 138 (69%) in gland tortuosity. The meiboscore showed significant difference with the increase of weight, BUT and BMI percentile ranking. The gland tortuosity showed significant difference with the increase of age, and BMI percentile ranking. Besides, shorter BUT corresponds to larger percentage of meibomian gland atrophy and higher OSDI score. Gender had no significant effect on gland dysfunction. The gland meiboscore was significantly correlated with weight, OSDI score, BUT, BMI percentile and BMI percentile ranking. And the gland tortuosity was significantly correlated with weight, BMI percentile and OSDI score.
In this pediatric population, the meiboscore become higher with the increase of weight, BMI percentile, OSDI and the decrease of BUT, and gland tortuosity became more serious with the increase of age and BMI percentile. Therefore, clinicians should be aware that being overweight is a risk factor for changes in meibomian gland structure.
探讨导致儿童睑板腺结构异常的因素。
招募200名儿童评估睑板腺形态。收集人口统计学和临床信息。使用眼表疾病指数（OSDI）问卷评估干眼疾病（DED）症状。进行睑板腺照相，并通过5分睑板腺评分量表（0 - 4）对腺体萎缩进行图像分级，通过3分评分量表（0 - 2）对腺体迂曲进行评分。
对200名年龄在10 - 18岁（13.10 ± 2.39岁）参与者的200只眼睛进行了成像。大多数患者睑板腺评分为1分，其中130例（65%），腺体迂曲评分为1分的有138例（69%）。睑板腺评分随体重、基础泪液分泌试验（BUT）和BMI百分位数排名的增加而有显著差异。腺体迂曲随年龄和BMI百分位数排名的增加有显著差异。此外，较短的BUT对应较高比例的睑板腺萎缩和较高的OSDI评分。性别对腺体功能障碍无显著影响。腺体睑板腺评分与体重、OSDI评分、BUT、BMI百分位数和BMI百分位数排名显著相关。腺体迂曲与体重、BMI百分位数和OSDI评分显著相关。
在该儿童群体中，睑板腺评分随体重、BMI百分位数、OSDI的增加以及BUT的降低而升高，腺体迂曲随年龄和BMI百分位数的增加而变得更严重。因此，临床医生应意识到超重是睑板腺结构改变的一个危险因素。
