Tusiimire Yvonne, Lubwama Michael, Ssekitoleko Robert Tamale, Koutsos Vasileios, Nuansing Wiwat, Radacsi Norbert
College of Engineering, Design, Art and Technology, Makerere University, P.O Box 7062, Kampala, Uganda.
Department of Polymer, Textiles and Industrial Engineering, Faculty of Engineering and Technology, Busitema University, P.O. Box 236, Tororo, Uganda.
Macromol Rapid Commun. 2025 Jul;46(13):e2500130. doi: 10.1002/marc.202500130. Epub 2025 May 12.
Electrospinning typically produces 2D fibrous nanofibers with poor heavy metal sorption capabilities and weak mechanical strength without post-processing treatment. Comparably, 3D structures have 99.992% porosity, larger pore sizes, and lower fiber density. In this study, macroscopic 3D poly L-lactic acid (PLLA) structures are fabricated successfully by 3D electrospinning. It is found that the electrospinning solvent system, polymer concentration, phosphoric acid (HPO) additive concentration, collector potential, working distance, flow rate, and applied nozzle voltage affected the fiber diameter and 3D structural dimensions. The effects of these variables are investigated, and optimum conditions are obtained. The optimal parameters for the 3D PLLA structure are 0.5 wt.% phosphoric acid additive to the 12 mg mL h PLLA solution, +1 V charged collector, +18 kV nozzle voltage, 4 cm working distance, 4 mL h flow rate, and Dichloromethane (DCM)/ N, N-dimethylformamide (DMF) (6:1) solvent. The structure has a 774 nm average diameter and 2.36 cm height. Scanning electron microscopy showed fiber uniformity at the different sections of the macroscopic 3D PLLA structures. These results expand the possibilities of using PLLA as 3D electrospun biomimetic structures.
静电纺丝通常会产生二维纤维状纳米纤维，在未经后处理的情况下，其重金属吸附能力较差且机械强度较弱。相比之下，三维结构具有99.992%的孔隙率、更大的孔径和更低的纤维密度。在本研究中，通过三维静电纺丝成功制备了宏观三维聚L-乳酸（PLLA）结构。研究发现，静电纺丝溶剂体系、聚合物浓度、磷酸（HPO）添加剂浓度、收集器电位、工作距离、流速和施加的喷嘴电压会影响纤维直径和三维结构尺寸。研究了这些变量的影响，并获得了最佳条件。三维PLLA结构的最佳参数为：在12mg/mL PLLA溶液中添加0.5wt.%的磷酸添加剂、+1V带电收集器、+18kV喷嘴电压、4cm工作距离、4mL/h流速以及二氯甲烷（DCM）/N，N-二甲基甲酰胺（DMF）（6:1）溶剂。该结构的平均直径为774nm，高度为2.36cm。扫描电子显微镜显示宏观三维PLLA结构不同截面处的纤维均匀性。这些结果拓展了将PLLA用作三维静电纺丝仿生结构的可能性。
