Infection prevention and control is a critical aspect of healthcare delivery, especially during the ongoing challenges posed by the coronavirus pandemic. Telemedicine has emerged as a valuable strategy for reducing the risk of infection transmission while maintaining the continuity of care. This systematic review evaluates the effectiveness, benefits, and challenges of telemedicine interventions aimed at improving infection prevention and control across various healthcare settings. A comprehensive literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines using databases including PubMed, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and the Virtual Health Library, covering studies published up to November 2024. Studies eligible for inclusion comprised randomized trials, observational studies, and mixed-methods research assessing telemedicine applications for infection control. The methodological quality of studies was assessed using established tools for qualitative and quantitative research appraisal. Five studies met the inclusion criteria and highlighted several positive outcomes. Telemedicine interventions such as mobile applications, remote video assessments of infection control practices, and virtual infection control consultations were associated with reduced infection rates, improved compliance with preventive protocols, and timely identification of procedural gaps. In inpatient settings, telemedicine also helped conserve protective equipment and reduce staff exposure. High patient satisfaction and maintained quality of care were commonly reported. However, several challenges were identified, including technical barriers, increased workload for healthcare workers, and concerns regarding data security. These findings suggest that telemedicine is a promising and adaptable solution for enhancing infection prevention efforts, but successful implementation depends on addressing operational barriers, ensuring adequate training, and strengthening infrastructure. Further rigorous research is needed to evaluate the long-term impact and cost-effectiveness of telemedicine in infection control.