Zu Biqi, Wang Ting, Pan Chunying, Li Wentao, An Libin, Yin Juan, Wu Yulan, Xu Junting, Li Dandan, Wu Xin, Xie Ziwei
School of Nursing, Dalian University, 116001 Dalian, Liaoning, China.
Nursing department, Dalian Seventh People's Hospital, 116023 Dalian, Liaoning, China.
Alpha Psychiatry. 2025 Apr 21;26(2):39866. doi: 10.31083/AP39866. eCollection 2025 Apr.
To investigate the risk factors for relapse among elderly schizophrenia patients undergoing maintenance phase treatment, aiming to offer insights for relapse prevention in this population.
A survey was conducted of elderly schizophrenia patients in the maintenance phase who attended outpatient clinics at a specialized psychiatric hospital from October, 2021 to September, 2023. The survey included both general and clinical data. Univariate analysis and multivariate non-conditional logistic regression analysis were conducted to identify independent risk factors for relapse in elderly schizophrenic patients undergoing maintenance phase treatment. A receiver operating characteristic (ROC) curve was drawn based on logistic regression results and the area under the curve (AUC) was used to evaluate the predictive value of each risk factor for relapse studied in these patients.
A total of 247 patients were collected, with 225 patients included in the analysis: 75 in the recurrence group and 150 in the non-recurrence group. Multivariate logistic regression analysis indicated: Irregular medication status (odds ratio (OR) = 3.302, 95% confidence interval (CI): 1.386-7.871), low exercise frequency (OR = 2.770, 95% CI: 1.141-6.726), family care points (OR = 0.647, 95% CI: 0.514-0.813), life event points (OR = 1.353, 95% CI: 1.194-1.533), and sleep duration (OR = 0.630, 95% CI: 0.504-0.788) as independent influencing factors for relapse during the maintenance phase of elderly patients with schizophrenia. The AUC for predicting relapse varied among these factors: Medication status (AUC: 0.660, 95% CI: 0.594-0.726), exercise frequency (AUC: 0.663, 95% CI: 0.599-0.727), family care (AUC: 0.691, 95% CI: 0.618-0.764), life events (AUC: 0.792, 95% CI: 0.731-0.853), and sleep duration (AUC: 0.789, 95% CI: 0.718-0.859). When considering all influencing factors, the AUC for predicting relapse during maintenance phase treatment of elderly patients with schizophrenia was 0.908 (95% CI: 0.867-0.949).
Medication status, exercise frequency, family care, life events and sleep duration emerged as independent influencing factors for relapse among elderly schizophrenia patients during maintenance phase treatment. Paying attention to these influencing factors simultaneously is suggested to prevent recurrence.
探讨老年精神分裂症患者维持期治疗复发的危险因素，旨在为该人群的复发预防提供见解。
对2021年10月至2023年9月在某专科医院门诊就诊的老年精神分裂症维持期患者进行调查。调查内容包括一般资料和临床资料。采用单因素分析和多因素非条件logistic回归分析，确定老年精神分裂症维持期治疗患者复发的独立危险因素。根据logistic回归结果绘制受试者工作特征（ROC）曲线，用曲线下面积（AUC）评估各研究危险因素对这些患者复发的预测价值。
共收集247例患者，纳入分析225例：复发组75例，未复发组150例。多因素logistic回归分析显示：用药不规律（比值比（OR）=3.302，95%置信区间（CI）：1.386 - 7.871）、运动频率低（OR = 2.770，95%CI：1.141 - 6.726）、家庭关怀得分（OR = 0.647，95%CI：0.514 - 0.813）、生活事件得分（OR = 1.353，95%CI：1.194 - 1.533）、睡眠时间（OR = 0.630，95%CI：0.504 - 0.788）为老年精神分裂症患者维持期复发的独立影响因素。这些因素预测复发的AUC有所不同：用药情况（AUC：0.660，95%CI：0.594 - 0.726）、运动频率（AUC：0.663，95%CI：0.599 - 0.727）、家庭关怀（AUC：0.691，95%CI：0.618 - 0.764）、生活事件（AUC：0.792，95%CI：0.731 - 0.853）、睡眠时间（AUC：0.789，95%CI：
