Scarpato N, Postiglione A
Ric Clin Lab. 1985;15 Suppl 1:499-504.
Several non-pharmacological treatments have been tested for homozygous familial hypercholesterolemia and, among these, plasma-exchange has been the most safe and effective. A recent development of this procedure is LDL-apheresis, that is the selective removal of atherogenic LDL and the return to the patient of his own LDL-depleted plasma. The method is based on the flowing of hypercholesterolemic plasma on sepharose columns with bound anti-LDL antibodies.
针对纯合子家族性高胆固醇血症，已经对几种非药物治疗方法进行了测试，其中血浆置换是最安全有效的。该程序的最新进展是低密度脂蛋白分离术，即选择性去除致动脉粥样硬化的低密度脂蛋白，并将患者自身去除低密度脂蛋白的血浆回输给他。该方法基于高胆固醇血症血浆在结合了抗低密度脂蛋白抗体的琼脂糖柱上流动。
