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肿瘤坏死因子-α和白细胞介素-1单核苷酸多态性与偏头痛发生风险的相关性。

Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development.

作者信息

Huang Guijiao, Dong Xin, Shao Xiaojiao, Wu Mengping, Gao Shan, Wang Yixuan, Guan Xinying

机构信息

Department of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University/ Lianyungang Training Base of Jinzhou Medical University/ The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, China.

Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

出版信息

Front Genet. 2025 Apr 25;16:1556498. doi: 10.3389/fgene.2025.1556498. eCollection 2025.

DOI:10.3389/fgene.2025.1556498
PMID:40352790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12061721/
Abstract

BACKGROUND

Migraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population.

METHODS

The research analyzed specific genetic variations-TNF-α -308 G/A, TNF-α -857 C/T, TNF-α -238G/A, IL1B-3953 C/T, and IL1RN -2018T/C SNPs-within 212 migraine patients and 210 healthy controls. Utilizing SNaPshot technology, scientists genotyped these markers related to TNF-α and IL-1 genes.

RESULTS

Findings revealed a significant association between the IL1B-3953 C/T SNP and migraine susceptibility, particularly noting its link with a familial history of the disorder. The presence of the C allele at this location was more prevalent in migraine sufferers. Multivariate analysis reinforced this connection, indicating the C allele under a dominant model as an independent risk factor for migraine (OR = 2.315, 95%CI: 1.053-5.090, P = 0.037). Additionally, the study observed a sex-specific difference regarding the TNF-α -857 C/T SNP among migraine patients.

CONCLUSION

Overall, this investigation contributes to understanding the genetic underpinnings of migraine in the Han Chinese population, highlighting the IL1B-3953 C/T SNP as a potential biomarker for migraine susceptibility.

摘要

背景

偏头痛是一种由神经和血管异常并伴有炎症参与引起的疾病，在一项针对中国汉族人群的病例对照研究中对其进行了调查。

方法

该研究分析了212例偏头痛患者和210例健康对照者的特定基因变异——TNF-α -308 G/A、TNF-α -857 C/T、TNF-α -238G/A、IL1B-3953 C/T和IL1RN -2018T/C单核苷酸多态性（SNP）。科学家们利用SNaPshot技术对这些与TNF-α和IL-1基因相关的标记进行基因分型。

结果

研究结果显示IL1B-3953 C/T SNP与偏头痛易感性之间存在显著关联，尤其指出其与该疾病家族史的联系。在这个位置存在的C等位基因在偏头痛患者中更为普遍。多变量分析强化了这种关联，表明在显性模型下C等位基因是偏头痛的独立危险因素（OR = 2.315，95%CI：1.053 - 5.090，P = 0.037）。此外，该研究在偏头痛患者中观察到TNF-α -857 C/T SNP存在性别特异性差异。

结论

总体而言，这项研究有助于了解汉族人群偏头痛的遗传基础，突出了IL1B-3953 C/T SNP作为偏头痛易感性潜在生物标志物的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd82/12061721/a2d416102f3b/fgene-16-1556498-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd82/12061721/ec0b34a406ff/fgene-16-1556498-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd82/12061721/a2d416102f3b/fgene-16-1556498-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd82/12061721/ec0b34a406ff/fgene-16-1556498-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd82/12061721/a2d416102f3b/fgene-16-1556498-g002.jpg

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本文引用的文献

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Enlightening the association between TNF-α -308 G > A and migraine: a meta-analysis with meta-regression and trial sequential analysis.揭示 TNF-α-308 G > A 与偏头痛之间的关联：一项荟萃分析及荟萃回归和试验序贯分析。
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