Lee In Ho, Lee Seung Jae, Moon Ju Ik, Lee Sang Eok, Sung Nak Song, Kwon Seong Uk, Bae In Eui, Rho Seung Jae, Kim Sung Gon, Kim Min Kyu, Yoon Dae Sung, Choi Won Jun, Choi In Seok
Department of Surgery, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.
Ann Surg Treat Res. 2025 May;108(5):310-316. doi: 10.4174/astr.2025.108.5.310. Epub 2025 Apr 28.
Common bile duct (CBD) stone recurrence after laparoscopic CBD exploration (LCBDE) is relatively common. No studies have been conducted evaluating the safety and feasibility of re-do LCBDE in the treatment of recurrent CBD stones.
This single-center retrospective study reviewed 340 consecutive patients who underwent LCBDE for CBD stones between January 2004 and December 2020. Patients with pancreatobiliary malignancies and those who underwent other surgical procedures were excluded.
Of the 340 included patients, 45 experienced a recurrence after a mean follow-up period of 24.2 months. Of them, 18 underwent re-do LCBDE, 20 underwent endoscopic intervention, 2 underwent radiologic intervention, and 5 underwent observation. Re-do LCBDE and initial LCBDE showed similar surgical outcomes in terms of operative time (113.1 minutes 107.5 minutes, P = 0.515), estimated blood loss (42.5 mL 49.1 mL, P = 0.661), open conversion rate (2.9% 0%, P = 0.461), postoperative complication (15.3% 22.2%, P = 0.430), and postoperative hospital stay (6.5 days 6.4 days, P = 0.921). Comparing re-do LCBDE and nonsurgical treatment (endoscopic or radiologic), no statistically significant differences were noted in posttreatment complication (22.2% 13.6%, P = 0.477), hospital stay (6.4 days 7.3 days, P = 0.607), and recurrence (50.0% 36.4%, P = 0.385). The clearance rate was higher in the re-do LCBDE group than in the nonsurgical group (100% 81.8%, P = 0.057).
Compared to initial LCBDE and endoscopic or radiological treatments, re-do LCBDE for recurrent CBD stones is a treatment option worth considering in selected patients.
腹腔镜胆总管探查术(LCBDE)后胆总管(CBD)结石复发较为常见。尚未有研究评估再次行LCBDE治疗复发性CBD结石的安全性和可行性。
本单中心回顾性研究分析了2004年1月至2020年12月期间连续340例行LCBDE治疗CBD结石的患者。排除患有胰腺胆道恶性肿瘤的患者以及接受其他外科手术的患者。
在纳入研究的340例患者中,平均随访24.2个月后,有45例出现复发。其中,18例行再次LCBDE,20例行内镜干预,2例行放射介入治疗,5例行观察等待。再次LCBDE与初次LCBDE在手术时间(113.1分钟 vs 107.5分钟,P = 0.515)、估计失血量(42.5 mL vs 49.1 mL,P = 0.661)、中转开腹率(2.9% vs 0%,P = 0.461)、术后并发症(15.3% vs 22.2%,P = 0.430)以及术后住院时间(6.5天 vs 6.4天,P = 0.921)方面显示出相似的手术结果。比较再次LCBDE与非手术治疗(内镜或放射介入),在治疗后并发症(22.2% vs 13.6%,P = 0.477)、住院时间(6.4天 vs 7.3天,P = 0.607)和复发率(50.0% vs 36.4%,P = 0.385)方面未观察到统计学显著差异。再次LCBDE组的结石清除率高于非手术组(100% vs 81.8%,P = 0.057)。
与初次LCBDE以及内镜或放射治疗相比,再次LCBDE治疗复发性CBD结石对于部分选定患者而言是一个值得考虑的数据的治疗选择。