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一例罕见的伪装成塌陷性肾小球病的结核病病例。

A Rare Case of Tuberculosis Masquerading as Collapsing Glomerulopathy.

作者信息

Kotha Vishnu Keerthana, Bukka Vijay Chander, Niranjan M, Tiwari Ankit, Herur Siddharth, Swarnalatha G

机构信息

Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

出版信息

Indian J Nephrol. 2025 May-Jun;35(3):434-436. doi: 10.25259/ijn_443_23. Epub 2024 Jun 17.

DOI:10.25259/ijn_443_23
PMID:40352867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12065584/
Abstract

Collapsing glomerulopathy (CG), usually presents with renal dysfunction, hypertension and proteinuria. The etiology is uncertain, yet a number of associations, including many viral infections commonly have been reported. Tuberculosis (TB), one of the most common infections, is not known to cause CG. We report a case of severe renal dysfunction requiring dialysis who had collapsing glomerulopathy on biopsy and evidence of active pulmonary tuberculosis. Anti-tubercular therapy alone resulted in improvement in kidney function.

摘要

塌陷性肾小球病(CG)通常表现为肾功能不全、高血压和蛋白尿。其病因尚不确定,但已报道了许多关联因素,包括多种病毒感染。结核病(TB)是最常见的感染之一,目前尚不清楚它是否会导致CG。我们报告了一例严重肾功能不全需要透析的病例,该患者活检显示为塌陷性肾小球病,并有活动性肺结核的证据。单独抗结核治疗使肾功能得到改善。

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本文引用的文献

1
Collapsing glomerulopathy: a 30-year perspective and single, large center experience.塌陷性肾小球病:30年回顾及单一大中心经验
Clin Kidney J. 2017 Aug;10(4):443-449. doi: 10.1093/ckj/sfx029. Epub 2017 May 8.
2
Tuberculosis-associated collapsing glomerulopathy: remission after treatment.结核相关性塌陷性肾小球病:治疗后缓解。
Ren Fail. 2010 Jan;32(1):143-6. doi: 10.3109/08860220903368567.
3
Current views on collapsing glomerulopathy.关于塌陷性肾小球病的当前观点。
J Am Soc Nephrol. 2008 Jul;19(7):1276-81. doi: 10.1681/ASN.2007080926. Epub 2008 Feb 20.
4
Collapsing glomerulopathy.塌陷性肾小球病
J Am Soc Nephrol. 2006 Oct;17(10):2854-63. doi: 10.1681/ASN.2006030225. Epub 2006 Aug 16.
5
Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants.局灶节段性肾小球硬化病理变异型的临床和病理特征
Kidney Int. 2006 Mar;69(5):920-6. doi: 10.1038/sj.ki.5000160.
6
Collapsing glomerulopathy in a 16-year-old girl with pulmonary tuberculosis: the role of systemic inflammatory mediators.一名16岁肺结核女孩的塌陷性肾小球病:全身炎症介质的作用
Pediatr Dev Pathol. 2004 Mar-Apr;7(2):166-70. doi: 10.1007/s10024-003-3027-4. Epub 2004 Mar 17.