Perez-Castro Lizbeth, Alabi Busola, Nawas Afshan, Lafita-Navarro M Carmen, Shay Jerry, Conacci-Sorrell Maralice
The University of Texas Southwestern Medical Center, Dallas, Texas, United States.
MicroPubl Biol. 2025 Apr 25;2025. doi: 10.17912/micropub.biology.001529. eCollection 2025.
This study investigates the role of the ligand-activated transcription factor AHR in repopulating the intestinal lining. Using organoid-derived cells and decellularized mouse intestinal scaffolds to investigate the importance of AHR in regulating intestinal regeneration, we found that silencing AHR expression hinders the capacity of colonic cells to repopulate decellularized colons. We therefore propose that AHR may play an important role in regulating intestinal regeneration. The ligand-dependent nature of AHR activity may provide an opportunity to interfere with disorders such as cancer and inflammatory bowel diseases which are caused by dysregulation in intestinal tissue renewal.
本研究调查了配体激活的转录因子芳烃受体（AHR）在肠道内衬再生中的作用。利用类器官衍生细胞和去细胞化的小鼠肠道支架来研究AHR在调节肠道再生中的重要性，我们发现沉默AHR表达会阻碍结肠细胞重新填充去细胞化结肠的能力。因此，我们认为AHR可能在调节肠道再生中发挥重要作用。AHR活性的配体依赖性特性可能为干预由肠道组织更新失调引起的疾病（如癌症和炎症性肠病）提供机会。
