Casto Florencia, Villaescusa Miguel, Jungberg Ezequiel, Saavedra Azcona Tomas, Lanusse Delfina, Plou Pedro, Baccanelli Matteo, Ajler Pablo
Department of Neurosurgery, Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina.
Department of Anesthesiology, Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina.
Surg Neurol Int. 2025 Apr 25;16:148. doi: 10.25259/SNI_791_2024. eCollection 2025.
Few studies have compared different topical hemostatic agents in live models or brain tissue, and their doses are not standardized. Little is known about the combined use of these different elements in terms of efficacy and safety, especially in neurosurgery. The objective of this study was to evaluate the efficacy of different topic hemostatic agents used in daily neurosurgical practice in an experimental animal model study.
A group of 42 Wistar rats was used. A stereotaxic frame was fixed, and coordinates were determined to locate the bregma. A 3 mm hole was drilled with a bone-profile burr on each side of the midline. A stylet was inserted into the brain to create the defect and induce bleeding. The rats were randomly divided into seven groups, with each group assigned a hemostatic agent. Hemostasis time and control time on the opposite side were measured.
Hemostasis was achieved after an average of 1 82 s in the group treated with Beriplast, making it the hemostatic agent that stopped the bleeding the fastest. The control time was an average of 40, 14 s. Compared with the negative control, all the agents resulted in significantly better hemostasis ( < 0.05).
A reduction in postoperative bleeding positively impacts annual morbidity and mortality rates, hospitalization time, and hospital bed turnover. Understanding the efficacy and safety of different hemostatic agents will enable surgeons to optimize intraoperative hemostasis, thereby achieving better postoperative outcomes and increased patient safety.
很少有研究在活体模型或脑组织中比较不同的局部止血剂，而且它们的剂量也未标准化。对于这些不同成分在疗效和安全性方面的联合使用知之甚少，尤其是在神经外科领域。本研究的目的是在实验动物模型研究中评估日常神经外科实践中使用的不同局部止血剂的疗效。
使用一组42只Wistar大鼠。固定立体定位框架，并确定坐标以定位前囟。在中线两侧用骨钻钻出一个3毫米的孔。将探针插入脑内以制造缺损并诱导出血。将大鼠随机分为七组，每组使用一种止血剂。测量止血时间和对侧的对照时间。
使用贝里普拉斯（Berioplast）治疗的组平均182秒后实现止血，使其成为止血最快的止血剂。对照时间平均为40.14秒。与阴性对照相比，所有药物的止血效果均明显更好（P<0.05）。
减少术后出血对年发病率、死亡率、住院时间和病床周转率有积极影响。了解不同止血剂的疗效和安全性将使外科医生能够优化术中止血，从而获得更好的术后效果并提高患者安全性。
