Hernáez Álvaro, Camps-Vilaró Anna, Polo-Alonso Sara, Subirana Isaac, Ramos Rafel, de Cid Rafael, Rodríguez-Artalejo Fernando, Elosua Roberto, Chirlaque M Dolores, Amiano Pilar, Bermúdez-López Marcelino, Guevara Marcela, Cinza-Sanjurjo Sergio, Sánchez María-José, de León Antonio Cabrera, Laclaustra Martín, Rojo-Martínez Gemma, Guembe-Suescun María J, Pérez-Gómez Beatriz, Vega-Alonso Tomás, Torán-Monserrat Pere, Lora-Pablos David, Huerta José María, Valdivielso José M, Dégano Irene R, Félix-Redondo Francisco J, Gandarillas Ana María, Valdés Sergio, Mundet-Tuduri Xavier, Sánchez Pedro L, Martín-Sánchez Vicente, Rigo Fernando, Alonso-Sampedro Manuela, Moreno-Iribas Conchi, Martín-Escudero Juan Carlos, Delgado Elías, Grau Maria, Urrutia Inés, Ovejero Diana, Quintela Inés, Martí-Lluch Ruth, Blay Natalia, Banegas José R, Tizón-Marcos Helena, Gómez Jesús Humberto, Aizpurua Amaia, Castro-Boqué Eva, Delfrade Josu, Prieto-Díaz Miguel Ángel, Rodríguez-Barranco Miguel, Almeida-González Delia, Moreno-Franco Belén, Oualla-Bachiri Wasima, Sayón-Orea Carmen, Plans-Beriso Elena, Lozano José Eugenio, López-Lifante Víctor M, Cancelas-Navia Pilar, Cabrera-Castro Natalia, Cambray Serafí, Zacarías-Pons Lluís, Fernández-Bergés Daniel, Donoso-Navarro Encarnación, Maldonado-Araque Cristina, Franch-Nadal Josep, Dorado-Díaz Pedro Ignacio, Villarín-Castro Alejandro, Frontera-Juan Guillem, Gude Francisco, Andueza Naroa, Téllez-Plaza María, Ares-Blanco Jessica, Cruz Raquel, Ribas-Aulinas Marc, Barretina Jordi, Guallar-Castillón Pilar, Caínzos-Achirica Miguel, Colorado-Yohar Sandra Milena, Llorente Adrián, Diaz-Tocados Juan Miguel, Ardanaz Eva, Micó-Pérez Rafael Manuel, Fernandez-Martinez Nicolás Francisco, Del Cristo Rodríguez-Pérez María, Cenarro Ana, Calle-Pascual Alfonso L, Marrugat Jaume
REGICOR Study Group, Hospital del Mar Research Institute (IMIM), Carrer Doctor Aiguader 88, 08003, Barcelona, Spain.
CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.
Eur J Epidemiol. 2025 May 12. doi: 10.1007/s10654-025-01229-6.
The CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this population, improve predictions of cardiovascular incidence using genomic and clinical data, and identify subgroups that would benefit most from targeted pharmacological and lifestyle interventions. CORDELIA includes 196,632 individuals (ages 18-84, 54% female, 96% born in Spain, 20% with higher education, recruited from 1989 to 2020, with follow-up periods ranging from 5 to 30 years), with DNA samples available for 117,342 participants (60%). Of the participants, 24% were current smokers, 43% hypertensive, 11% diabetic, 15% medicated with lipid-lowering drugs, 44% overweight, and 27% obese. If not already available, genotyping is being performed using the Axiom™ Spain Biobank array (~ 750,000 variants, including 115,000 specific and 50,000 rare functional variants from the Spanish population). The cohort also includes incident events (coronary heart disease, stroke, heart failure, peripheral artery disease, hypertension, diabetes); date and cause of death; and harmonized data on risk factors (body mass index, waist circumference, lipid profile, blood pressure, glucose, creatinine), lifestyle (smoking, physical activity, diet, alcohol), and socioeconomic status. 99,019 participants (50%) also provide plasma samples. CORDELIA will significantly contribute to understanding the complex interplay of risk factors contributing to cardiovascular disease and advance the fields of precision medicine and public health in Southern European individuals.
CORDELIA研究（重新整合协作队列数据以研究慢性病机制和长期发病率）合并了35个西班牙人群队列，以调查南欧人群中心血管疾病的临床、环境、遗传和组学决定因素。其目标是针对该人群开展迄今为止最大规模的心血管疾病全基因组关联研究，利用基因组和临床数据改进心血管疾病发病率预测，并识别出能从靶向药物和生活方式干预中获益最大的亚组。CORDELIA研究纳入了196,632名个体（年龄在18至84岁之间，女性占54%，96%出生于西班牙，20%接受过高等教育，于1989年至2020年招募，随访期为5至30年），其中117,342名参与者（60%）有可用的DNA样本。参与者中，24%为当前吸烟者，43%患有高血压，11%患有糖尿病，15%服用降脂药物，44%超重，27%肥胖。若尚未进行基因分型，则使用Axiom™西班牙生物样本库芯片（约75万个变异位点，包括来自西班牙人群的11.5万个特定变异位点和5万个罕见功能变异位点）进行基因分型。该队列还包括发病事件（冠心病、中风、心力衰竭、外周动脉疾病、高血压、糖尿病）；死亡日期和原因；以及关于危险因素（体重指数、腰围、血脂谱、血压、血糖、肌酐）、生活方式（吸烟、体力活动、饮食、饮酒）和社会经济地位的统一数据。99,019名参与者（50%）还提供了血浆样本。CORDELIA研究将为理解导致心血管疾病的危险因素之间复杂的相互作用做出重大贡献，并推动南欧个体精准医学和公共卫生领域的发展。
