Meng Zhao-Yang, Yang Lin, Zhou Peng
Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Ophthalmology, Visionly Plus Eye Hospital, Beijing, China.
PLoS One. 2025 May 12;20(5):e0323546. doi: 10.1371/journal.pone.0323546. eCollection 2025.
This study aims to examine the short-term axial shortening effects of orthokeratology (ortho-K) lenses and investigate their mechanical mechanisms.
We conducted a retrospective analysis on 80 myopic children, aged 8-18, who wore ortho-K lenses for one week. Axial lengths were measured pre- and post-treatment using AL-Scan Optical Biometer. We developed a finite element model of the eye using ABAQUS software to explore mechanical changes.
A significant reduction in axial length was observed after one week of ortho-K lens wear, with an average decrease of 0.028 ± 0.032 mm (P = 4.02 x 10-11). Approximately 82.5% of participants exhibited axial length reduction. The biomechanical model indicated that ortho-K lenses exerted forces altering the tension dynamics within the ocular structure, notably decreasing tension in the posterior ciliary muscle-lens complex. This differential change in tension may account for the mechanical basis of the observed short-term reduction in axial length.
Orthokeratology lenses induce a short-term shortening in axial length, likely due to mechanical changes in ocular tension dynamics. The finite element model suggests that these lenses decrease posterior ciliary-lens complex tension, leading to axial shortening. These findings enhance comprehension of the mechanical basis for myopia control via ortho-K treatment, highlighting potential avenues for further applied research in myopia management.
本研究旨在探讨角膜塑形术(ortho-K)镜片的短期轴向缩短效应,并研究其力学机制。
我们对80名年龄在8至18岁之间佩戴ortho-K镜片一周的近视儿童进行了回顾性分析。使用AL-Scan光学生物测量仪在治疗前后测量眼轴长度。我们使用ABAQUS软件建立了眼睛的有限元模型,以探索力学变化。
佩戴ortho-K镜片一周后,观察到眼轴长度显著缩短,平均减少0.028±0.032毫米(P = 4.02×10-11)。约82.5%的参与者眼轴长度减少。生物力学模型表明,ortho-K镜片施加的力改变了眼内结构的张力动态,特别是降低了睫状肌-晶状体后复合体的张力。这种张力的差异变化可能是观察到的眼轴长度短期缩短的力学基础。
角膜塑形术镜片可导致眼轴长度短期缩短,可能是由于眼内张力动态的力学变化所致。有限元模型表明,这些镜片降低了睫状肌-晶状体后复合体的张力,导致眼轴缩短。这些发现增强了对通过角膜塑形术治疗控制近视的力学基础的理解,突出了近视管理中进一步应用研究的潜在途径。