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角膜塑形镜引起的眼轴缩短分析及其力学机制。

Analysis of axial shortening induced by orthokeratology lenses and its mechanical mechanisms.

作者信息

Meng Zhao-Yang, Yang Lin, Zhou Peng

机构信息

Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Department of Ophthalmology, Visionly Plus Eye Hospital, Beijing, China.

出版信息

PLoS One. 2025 May 12;20(5):e0323546. doi: 10.1371/journal.pone.0323546. eCollection 2025.

Abstract

PURPOSE

This study aims to examine the short-term axial shortening effects of orthokeratology (ortho-K) lenses and investigate their mechanical mechanisms.

METHODS

We conducted a retrospective analysis on 80 myopic children, aged 8-18, who wore ortho-K lenses for one week. Axial lengths were measured pre- and post-treatment using AL-Scan Optical Biometer. We developed a finite element model of the eye using ABAQUS software to explore mechanical changes.

RESULTS

A significant reduction in axial length was observed after one week of ortho-K lens wear, with an average decrease of 0.028 ± 0.032 mm (P = 4.02 x 10-11). Approximately 82.5% of participants exhibited axial length reduction. The biomechanical model indicated that ortho-K lenses exerted forces altering the tension dynamics within the ocular structure, notably decreasing tension in the posterior ciliary muscle-lens complex. This differential change in tension may account for the mechanical basis of the observed short-term reduction in axial length.

CONCLUSION

Orthokeratology lenses induce a short-term shortening in axial length, likely due to mechanical changes in ocular tension dynamics. The finite element model suggests that these lenses decrease posterior ciliary-lens complex tension, leading to axial shortening. These findings enhance comprehension of the mechanical basis for myopia control via ortho-K treatment, highlighting potential avenues for further applied research in myopia management.

摘要

目的

本研究旨在探讨角膜塑形术(ortho-K)镜片的短期轴向缩短效应,并研究其力学机制。

方法

我们对80名年龄在8至18岁之间佩戴ortho-K镜片一周的近视儿童进行了回顾性分析。使用AL-Scan光学生物测量仪在治疗前后测量眼轴长度。我们使用ABAQUS软件建立了眼睛的有限元模型,以探索力学变化。

结果

佩戴ortho-K镜片一周后,观察到眼轴长度显著缩短,平均减少0.028±0.032毫米(P = 4.02×10-11)。约82.5%的参与者眼轴长度减少。生物力学模型表明,ortho-K镜片施加的力改变了眼内结构的张力动态,特别是降低了睫状肌-晶状体后复合体的张力。这种张力的差异变化可能是观察到的眼轴长度短期缩短的力学基础。

结论

角膜塑形术镜片可导致眼轴长度短期缩短,可能是由于眼内张力动态的力学变化所致。有限元模型表明,这些镜片降低了睫状肌-晶状体后复合体的张力,导致眼轴缩短。这些发现增强了对通过角膜塑形术治疗控制近视的力学基础的理解,突出了近视管理中进一步应用研究的潜在途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6149/12068609/94640dd5b233/pone.0323546.g001.jpg

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