Huang Xuanchun, Hu Lanshuo, Li Jun, Meng Chao, Xia Xiao, Liu Yiying
Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing, China.
Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing, China.
Sci Rep. 2025 May 12;15(1):16483. doi: 10.1038/s41598-025-01122-y.
To investigate the association between dietary microbes intake and sedentary behavior with mortality risk in hypertensive adults in the United States. This study uses data from hypertensive individuals included in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The relationship between live-microbe intake, sedentary time, and mortality risk among hypertensive individuals is preliminarily explored using Kaplan-Meier curves. Cox proportional hazards models are employed to analyze the associations separately and jointly, followed by subgroup analyses and sensitivity analysis to assess model stability. The study enrolled 10,036 participants with hypertension, among whom 1599 deaths occurred, including 512 cardiovascular disease-related deaths. Initial Kaplan-Meier curve analysis revealed that hypertensive individuals with both low intake of dietary live microbes and prolonged sedentary time had significantly higher mortality risk. Subsequent Cox proportional hazards model analysis demonstrated that high dietary microbial intake combined with reduced sedentary time were associated with lower mortality risk in hypertensive patients. Joint effect analysis suggested that maintaining proper dietary microbial eating habit may mitigate the adverse health effects of chronic sedentary behavior in this population. Subgroup and sensitivity analyses confirmed the stability of these findings across most examined conditions. The mortality risk in hypertensive individuals due to low intake of dietary live microbes and prolonged sedentary behavior is cumulative. Consuming foods rich in dietary microbes may help reduce the mortality risk associated with sedentary behavior in hypertensive populations.
旨在研究美国高血压成年人饮食中微生物摄入量和久坐行为与死亡风险之间的关联。本研究使用了1999年至2018年美国国家健康与营养检查调查（NHANES）中高血压个体的数据。使用Kaplan-Meier曲线初步探索高血压个体中活微生物摄入量、久坐时间与死亡风险之间的关系。采用Cox比例风险模型分别和联合分析这些关联，随后进行亚组分析和敏感性分析以评估模型稳定性。该研究纳入了10,036名高血压参与者，其中1599人死亡，包括512例与心血管疾病相关的死亡。最初的Kaplan-Meier曲线分析显示，饮食中活微生物摄入量低且久坐时间长的高血压个体死亡风险显著更高。随后的Cox比例风险模型分析表明，高饮食微生物摄入量与减少久坐时间相结合与高血压患者较低的死亡风险相关。联合效应分析表明，保持适当的饮食微生物饮食习惯可能减轻该人群慢性久坐行为对健康的不利影响。亚组和敏感性分析证实了这些发现在大多数检查条件下的稳定性。高血压个体因饮食中活微生物摄入量低和久坐行为延长导致的死亡风险是累积的。食用富含饮食微生物的食物可能有助于降低高血压人群中与久坐行为相关的死亡风险。
