Swarup J Shanti, Thomas Rathika, Rucharitha Jessica, Arunkumar V R, V Vasanthi
Department of Pediatric and Preventive Dentistry, TamilNadu Government Dental College and Hospital, Chennai, India.
Research assistant, TamilNadu Government Dental College and Hospital, Chennai, India.
Evid Based Dent. 2025 May 12. doi: 10.1038/s41432-025-01146-3.
Hydroxyapatite (HAp) derived from chicken eggshells has recently gained significant interest in tissue engineering and regenerative medicine. This paper aims to review the synthesis, properties and applications of eggshell-derived hydroxyapatite (E-HAp) in dentistry.
A comprehensive literature search was conducted in PubMed and Scopus databases, along with a grey literature search. The references of selected studies were also manually reviewed to identify additional relevant articles. No restrictions were applied for language or publication year. Two independent reviewers carried out the study selection and data extraction processes.
Seventeen studies met the inclusion criteria and were included in the qualitative analysis. Most studies were in vitro investigations focused on applications such as dentinal tubule sealing (n = 4) and remineralization of initial enamel caries lesions (n = 4). E-HAp was also studied for tissue engineering applications, including alveolar ridge preservation as a bone graft material (n = 5) and periodontal regeneration (n = 2). Additional applications included regenerative endodontics (n = 3) and use as a pulp capping agent (n = 2).
E-HAp shows a wide range of applications in dentistry, particularly in tissue engineering and regenerative dentistry, marking it as a promising biomaterial in dentistry.
来源于鸡蛋壳的羟基磷灰石（HAp）最近在组织工程和再生医学领域引起了广泛关注。本文旨在综述蛋壳衍生羟基磷灰石（E-HAp）在牙科领域的合成、性质及应用。
在PubMed和Scopus数据库中进行了全面的文献检索，并进行了灰色文献检索。还人工查阅了所选研究的参考文献，以识别其他相关文章。对语言和发表年份未作限制。由两名独立的评审员进行研究选择和数据提取过程。
17项研究符合纳入标准并被纳入定性分析。大多数研究是体外研究，重点关注牙本质小管封闭（n = 4）和早期釉质龋损再矿化（n = 4）等应用。E-HAp还被研究用于组织工程应用，包括作为骨移植材料的牙槽嵴保存（n = 5）和牙周再生（n = 2）。其他应用包括再生牙髓治疗（n = 3）和用作牙髓盖髓剂（n = 2）。
E-HAp在牙科领域显示出广泛的应用，特别是在组织工程和再生牙科方面，使其成为牙科领域一种有前景的生物材料。
