Jin Yang, Li Kaihui, Liu Xining, Zhang Fang, Wang Xiao, Fei Lingxia, Tan Qinghua, Li Danfang, Wang Xiaobo, Wang Genbo, Chen Junxi, Hu Xiangshu
Department of Neurosurgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Department of Epilepsy Center, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
Brain Behav. 2025 May;15(5):e70537. doi: 10.1002/brb3.70537.
This study aims to explore the stimulation-induced eye movements (EMs) from various branches of the precentral sulcus (PrCS) and to learn if the epileptogenic area influences EMs effects.
The high-frequency direct electrical stimulation mapping reports were completed from patients with SEEG exploration. The counts of gender, the distribution of EMs effects sites, the seizure onset age, course of epilepsy, age of stimulation, and stimulation intensity were analyzed. The correlation factors of the EMs positive cases were studied through the multivariate regression method.
The PrCS through 778 contacts of 77 patients was studied from July 2015 to December 2020. A total of 18 patients showed induced EMs in the PrCS. The average stimulation intensity was 22.0 ± 1.3 mA. In positive cases, 279 contacts were explored on the PrCS, and 24.51% were positive. Overall, 60.32% sites were in the superior PrCS (SP), and 39.68% sites were in the inferior PrCS (IP). The SP was more likely to have a stimulating response to EMs than the IP (p = 0.017). The major EM effect was deviation, with a total of 39.68% positive sites in 11 cases, namely, 16 sites in the SP and 9 sites in the IP. Multiple regression analysis indicated that the positive EMs cases were only correlated with whether seizure onset zone (SOZ) was located on prCS (p = 0.004), but not with age of onset, duration, frequency of seizures, preoperative intelligence quotient (IQ), and age of stimulation.
Deviation was the major type of positive EMs by directly stimulating the prCS. The SP was more sensitive to stimulation than the inferior branch was. The positive EM's chance showed a certain correlation with whether the prCS was inside the SOZ or not.
本研究旨在探索中央前沟（PrCS）各分支的刺激诱发眼动（EMs），并了解致痫区域是否影响EMs效应。
完成了来自立体定向脑电图（SEEG）探索患者的高频直接电刺激图谱报告。分析了性别计数、EMs效应部位分布、癫痫发作起始年龄、癫痫病程、刺激年龄和刺激强度。通过多元回归方法研究了EMs阳性病例的相关因素。
2015年7月至2020年12月，对77例患者的778个触点的PrCS进行了研究。共有18例患者在PrCS中出现诱发性EMs。平均刺激强度为22.0±1.3mA。在阳性病例中，对PrCS上的279个触点进行了探索，其中24.51%为阳性。总体而言，60.32%的部位位于中央前沟上部（SP），39.68%的部位位于中央前沟下部（IP）。与IP相比，SP对EMs的刺激反应更可能出现（p = 0.017）。主要的EMs效应是偏斜，11例中共有39.68%的阳性部位，即SP中有16个部位，IP中有9个部位。多元回归分析表明，EMs阳性病例仅与癫痫发作起始区（SOZ）是否位于PrCS上相关（p = 0.004），而与发作年龄、病程、癫痫发作频率、术前智商（IQ）和刺激年龄无关。
直接刺激PrCS时，偏斜是阳性EMs的主要类型。SP比下部分支对刺激更敏感。EMs阳性的几率与PrCS是否在SOZ内有一定相关性。
