Shi Wenru, Zhang Jie, Wei Sitong, Wang Xiang, Cao Hongfei, Ye Dongqing, Fang Xinyu
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China.
Front Oncol. 2025 Apr 28;15:1557175. doi: 10.3389/fonc.2025.1557175. eCollection 2025.
Conflicting evidence exists on the link between gout and cancer risk, with limited clarity on the impact of healthy lifestyle factors.
In the UK Biobank, 7,169 gout patients were matched with 21,507 non-gout controls (1:3 ratio) using propensity scores. Cox regression models assessed cancer risk associated with gout. Among 6,105 gout patients, cancer risk was further evaluated using an eight-factor Healthy Lifestyle Score (HLS) and a weighted HLS.
Gout was linked to a higher cancer incidence [HR (95% CI) = 1.075 (1.013-1.140)]. High HLS in gout patients correlated with a lower cancer risk [HR (95% CI) = 0.825 (0.717-0.948)], with the strongest protective effect observed in those aged ≥60. Sensitivity analyses confirmed these findings.
Gout patients have a higher risk of developing cancer, but a healthy lifestyle, particularly in those aged 60 and older, significantly reduces this risk. These findings highlight the importance of lifestyle interventions for cancer prevention in patients with gout.
关于痛风与癌症风险之间的联系存在相互矛盾的证据，健康生活方式因素的影响尚不清楚。
在英国生物银行中，使用倾向评分将7169例痛风患者与21507例非痛风对照者（比例为1:3）进行匹配。Cox回归模型评估与痛风相关的癌症风险。在6105例痛风患者中，使用八因素健康生活方式评分（HLS）和加权HLS进一步评估癌症风险。
痛风与较高的癌症发病率相关[HR（95%CI）=1.075（1.013-1.140）]。痛风患者的高HLS与较低的癌症风险相关[HR（95%CI）=0.825（0.717-0.948）]，在60岁及以上人群中观察到最强的保护作用。敏感性分析证实了这些发现。
痛风患者患癌症的风险较高，但健康的生活方式，尤其是在60岁及以上人群中，可显著降低这种风险。这些发现凸显了生活方式干预对痛风患者预防癌症的重要性。
