Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.
Department of Research Methodology and Biostatistics, School of Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam.
Sci Rep. 2023 Aug 23;13(1):13765. doi: 10.1038/s41598-023-40819-w.
Combinations of lifestyle behaviors may lead to different cancer risks. This study aimed to identify the latent classes based on lifestyle behavior trajectories and to investigate the association between these latent classes and cancer risk. Participants in the 2002-2003 National Health Insurance Service general health examination were included. Data on smoking, alcohol drinking, body mass index (BMI), and physical activity measured four times between 2002 and 2009 were analyzed. Incident cancer cases were tracked from 2010 to 2018. Patterns of alcohol drinking, smoking, BMI, and physical activity and latent classes based on trajectories of smoking, alcohol drinking, BMI, and physical activity were identified. Among 2,735,110 adults (1,787,486 men and 947,624 women), 111,218 (69,089 men and 42,129 women) developed incident cancer. Six latent classes of lifestyle behavior were identified, with Class 1 (healthy class) involving only 0.2% of men and 0.5% of women. The highest risk class in males tended to be steady light drinkers and steady moderate smokers, have steady low frequency of physical activity, and be obese. This class showed a 1.47 times higher (95% CI = 1.29-1.69) risk of all cancers than did the healthy class. Among women, there was only an association between the highest risk class (tendency to be non-drinkers, light smokers) and colorectal cancer (HR = 1.70, 95% CI = 1.02-2.83). Only a small percentage of participants maintained a long-term healthy lifestyle. Identifying classes of behavior combinations and their links to cancer development is therefore critical for cancer prevention.
生活方式行为的组合可能会导致不同的癌症风险。本研究旨在根据生活方式行为轨迹确定潜在类别，并研究这些潜在类别与癌症风险之间的关联。研究对象为参加 2002-2003 年国家健康保险服务综合健康检查的人群。分析了 2002 年至 2009 年期间四次测量的吸烟、饮酒、体重指数（BMI）和身体活动数据。从 2010 年至 2018 年跟踪癌症发病情况。确定了饮酒、吸烟、BMI 和身体活动的模式以及基于吸烟、饮酒、BMI 和身体活动轨迹的潜在类别。在 2735110 名成年人（1787486 名男性和 947624 名女性）中，有 111218 名（69089 名男性和 42129 名女性）发生了癌症。确定了六种生活方式行为的潜在类别，其中第 1 类（健康类别）仅涉及 0.2%的男性和 0.5%的女性。男性中风险最高的类别往往是稳定的轻度饮酒者和稳定的中度吸烟者，身体活动频率稳定较低，且肥胖。与健康类别相比，该类别所有癌症的风险增加了 1.47 倍（95%CI=1.29-1.69）。在女性中，只有最高风险类别（非饮酒者、轻度吸烟者）与结直肠癌相关（HR=1.70，95%CI=1.02-2.83）。只有一小部分参与者长期保持健康的生活方式。因此，确定行为组合的类别及其与癌症发展的关系对于癌症预防至关重要。
