Blank Heidi M, No Eun-Gyu, Polymenis Michael
Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd., College Station, Texas 77843, U.S.A.
Biochem Soc Trans. 2025 May 9;53(2):BST20253004. doi: 10.1042/BST20253004.
Cells adjust their proliferation in response to extrinsic factors and nutrients. Such inputs must reach the cell cycle machinery to ensure proper cell proliferation. This minireview focuses on evidence suggesting that phosphorylating the T-loop domain of cyclin-dependent kinases may be a critical and conserved conduit for these external signals. Understanding this regulatory mechanism could provide crucial insights into how all eukaryotic cells integrate external information to decide whether or not to divide.
细胞会根据外在因素和营养物质来调节自身的增殖。这些输入信号必须传递到细胞周期机制，以确保细胞的正常增殖。本综述聚焦于相关证据，这些证据表明，对细胞周期蛋白依赖性激酶的T环结构域进行磷酸化修饰，可能是这些外部信号的关键且保守的传导途径。了解这一调控机制，可为深入理解所有真核细胞如何整合外部信息以决定是否进行分裂提供关键线索。
