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丘脑后内侧在纹状体神经回路调节及选择行为中的作用。

Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior.

作者信息

Yonk Alex J, Linares-García Ivan, Pasternak Logan, Juliani Sofia E, Gradwell Mark A, George Arlene J, Margolis David J

机构信息

Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, United States.

出版信息

Elife. 2025 May 13;13:RP98563. doi: 10.7554/eLife.98563.

DOI:10.7554/eLife.98563
PMID:40359003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12074639/
Abstract

The posterior medial (POm) thalamus is heavily interconnected with sensory and motor circuitry and is likely involved in behavioral modulation and sensorimotor integration. POm provides axonal projections to the dorsal striatum, a hotspot of sensorimotor processing, yet the role of POm-striatal projections has remained undetermined. Using optogenetics with mouse brain slice electrophysiology, we found that POm provides robust synaptic input to direct and indirect pathway striatal spiny projection neurons (D1- and D2-SPNs, respectively) and parvalbumin-expressing fast spiking interneurons (PVs). During the performance of a whisker-based tactile discrimination task in head-restrained mice, POm-striatal projections displayed learning-related activation correlating with anticipatory, but not reward-related, pupil dilation. Inhibition of POm-striatal axons across learning caused slower reaction times and an increase in the number of training sessions for expert performance. Our data indicate that POm-striatal inputs provide a behaviorally relevant arousal-related signal, which may prime striatal circuitry for efficient integration of subsequent choice-related inputs.

摘要

丘脑后内侧（POm）与感觉和运动回路高度互联，可能参与行为调节和感觉运动整合。POm向背侧纹状体提供轴突投射，背侧纹状体是感觉运动处理的热点区域，但POm-纹状体投射的作用尚未确定。通过将光遗传学与小鼠脑片电生理学相结合，我们发现POm为直接和间接通路的纹状体棘状投射神经元（分别为D1和D2-SPN）以及表达小白蛋白的快速放电中间神经元（PVs）提供强大的突触输入。在头部固定的小鼠执行基于触须的触觉辨别任务期间，POm-纹状体投射表现出与学习相关的激活，与预期性瞳孔扩张相关，但与奖励无关。在学习过程中抑制POm-纹状体轴突会导致反应时间延长，达到专家表现所需的训练次数增加。我们的数据表明，POm-纹状体输入提供了一种与行为相关的唤醒相关信号，这可能使纹状体回路为有效整合后续与选择相关的输入做好准备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/a65217fbf572/elife-98563-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/eab5312aa71d/elife-98563-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/97e0a070553e/elife-98563-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/0c663f545bfa/elife-98563-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/17c3c7fe999f/elife-98563-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/1c7df40fd168/elife-98563-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/9f29fb27249f/elife-98563-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/a65217fbf572/elife-98563-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/eab5312aa71d/elife-98563-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/fe18f3048262/elife-98563-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/5317cd62ebf6/elife-98563-fig1-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/97e0a070553e/elife-98563-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/0c663f545bfa/elife-98563-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/17c3c7fe999f/elife-98563-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/1c7df40fd168/elife-98563-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/9f29fb27249f/elife-98563-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4640/12074639/a65217fbf572/elife-98563-fig4-figsupp1.jpg

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本文引用的文献

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2
A transthalamic pathway crucial for perception.经丘脑的感觉传导束对于感知至关重要。
Nat Commun. 2024 Jul 26;15(1):6300. doi: 10.1038/s41467-024-50163-w.
3
Co-coding of head and whisker movements by both VPM and POm thalamic neurons.VPM 和 POm 丘脑神经元共同编码头部和胡须运动。
Nat Commun. 2024 Jul 13;15(1):5883. doi: 10.1038/s41467-024-50039-z.
4
GABAergic regulation of striatal spiny projection neurons depends upon their activity state.GABA 能神经元对纹状体棘状投射神经元的调节依赖于其活动状态。
PLoS Biol. 2024 Jan 31;22(1):e3002483. doi: 10.1371/journal.pbio.3002483. eCollection 2024 Jan.
5
Cell-Type Specific Connectivity of Whisker-Related Sensory and Motor Cortical Input to Dorsal Striatum.触须相关感觉和运动皮层输入到背侧纹状体的细胞类型特异性连接。
eNeuro. 2024 Jan 29;11(1). doi: 10.1523/ENEURO.0503-23.2023. Print 2024 Jan.
6
Acetylcholine waves and dopamine release in the striatum.纹状体中的乙酰胆碱波和多巴胺释放。
Nat Commun. 2023 Oct 27;14(1):6852. doi: 10.1038/s41467-023-42311-5.
7
External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice.外苍白球向背侧纹状体的传入调节雄性小鼠的习惯性寻求行为。
Nat Commun. 2023 Jul 12;14(1):4085. doi: 10.1038/s41467-023-39545-8.
8
The role of the parafascicular thalamic nucleus in action initiation and steering.扣带旁核在动作启动和导向中的作用。
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9
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10
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Front Syst Neurosci. 2022 Dec 8;16:1045764. doi: 10.3389/fnsys.2022.1045764. eCollection 2022.