Adherens junctions co-opt EGFR-ERK signaling for epithelial mechanotransduction.
作者信息
Potoczky Ellen K, Yap Alpha S
机构信息
Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072 Australia.
出版信息
Sci Signal. 2025 May 13;18(886):eadx0682. doi: 10.1126/scisignal.adx0682.
PMID:40359263
Abstract
In this issue of , Houtekamer . report a mechanism by which adherens junctions enable epithelia to respond to mechanical stress. They demonstrate that E-cadherin-containing adhesions stimulate ERK signaling in response to tissue tension through a metalloproteinase pathway that releases EGF receptor ligands.
摘要
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