Latimer K S, Rakich P M, Thompson D F
Vet Pathol. 1985 Jul;22(4):370-4. doi: 10.1177/030098588502200412.
Pelger-Huët anomaly was diagnosed in a young male cat on the basis of persistent nuclear hyposegmentation of blood granulocytes, absence of clinical disease or feline leukemia virus infection, and demonstration of genetic transmission of the anomaly. Neutrophils, eosinophils, basophils, and monocytes had significantly less nuclear segmentation when compared to similar leukocyte types from a control cat. On smears of bone marrow, megakaryocytes also appeared hyposegmented. A test mating with an unaffected queen produced a litter of five kittens (three males, two females). One male and one female kitten had the Pelger-Huët trait on examination of blood smears. Autosomal dominant transmission of this anomaly is suspected based on these findings.
根据血液粒细胞持续存在核分叶过少、无临床疾病或猫白血病病毒感染以及该异常的遗传传递证据，在一只年轻雄性猫中诊断出Pelger-Huët异常。与对照猫的相似白细胞类型相比，中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞和单核细胞的核分叶明显减少。在骨髓涂片上，巨核细胞也表现出核分叶过少。与一只未受影响的母猫进行的测交产生了一窝五只小猫（三只雄性，两只雌性）。对血液涂片检查发现，一只雄性和一只雌性小猫具有Pelger-Huët特征。基于这些发现，怀疑该异常为常染色体显性遗传。
