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氟争议的事实与谬误:当代视角

Facts and Fallacies of the Fluoride Controversy: A Contemporary Perspective.

作者信息

Samaranayake Lakshman, Porntaveetus Thantrira, Tsoi James, Tuygunov Nozimjon

机构信息

Center of Excellence in Precision Medicine and Digital Health, Geriatric Dentistry and Special Patients Care Program, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Dr DY Patil Dental College and Hospital, Dr DY Patil Vidyapeeth, Pimpri, Pune, India; Faculty of Dentistry, University of Hong Kong, 34 Hospital Road, Hong Kong.

Center of Excellence in Precision Medicine and Digital Health, Geriatric Dentistry and Special Patients Care Program, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

出版信息

Int Dent J. 2025 May 12;75(4):100833. doi: 10.1016/j.identj.2025.04.013.

DOI:10.1016/j.identj.2025.04.013
PMID:40359684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12141933/
Abstract

Fluoride is a natural element recognized for its dental benefits. Fluoride prevents caries due to its antimicrobial activity, enhancing enamel resistance and promoting remineralization After decades of fluoridation of municipal water supplies to reduce dental caries, an intense debate has resurfaced regarding water fluoridation as a public health strategy to combat caries. This renewed discourse occurs against the backdrop of extensive data that clearly demonstrate the vital role of fluoride in caries prevention. Indeed, the Centres for Disease Control and Prevention has stated water fluoridation as 1 of the top ten public health interventions in the twentieth century. The FDI World Dental Federation also advocates systemic fluoride use as a cost-effective caries prevention strategy, and supports its inclusion in public health policies through a number of policy directives. This debate in the US has intensified as a Court concluded that water fluoridation poses unreasonable risks such as reduction of the intelligence quotient (IQ) in children. Additionally, recent statements from the leadership of the US Health and Human Services agency suggest that water fluoridation may cause more harm than good leading some states, like Utah, to revoke fluoridation mandates This article aims to provide a contemporary perspective on fluoride by revisiting its benefits, controversies, and potential risks. It highlights the dual role of fluoride in both individual oral care and public health and underscores the necessity for safe, equitable, and effective delivery strategies tailored to the needs of diverse populations, balancing its preventive advantages with potential health concerns. The review culminates with a summary of policy statements from the FDI World Dental Federation regarding the promotion of oral health through both systemic and topical fluoridation.

摘要

氟化物是一种天然元素,因其对牙齿有益而为人所知。氟化物因其抗菌活性可预防龋齿,增强牙釉质抵抗力并促进再矿化。在市政供水进行数十年氟化处理以减少龋齿之后,关于水氟化作为预防龋齿的公共卫生策略的激烈辩论再次浮出水面。这场新的讨论是在大量数据的背景下展开的,这些数据清楚地表明了氟化物在预防龋齿中的重要作用。事实上,美国疾病控制与预防中心已将水氟化列为20世纪十大公共卫生干预措施之一。国际牙科联合会也倡导系统使用氟化物作为一种具有成本效益的龋齿预防策略,并通过多项政策指令支持将其纳入公共卫生政策。在美国,这场辩论愈演愈烈,因为一家法院得出结论,水氟化会带来不合理的风险,如降低儿童智商。此外,美国卫生与公众服务部领导层最近的声明表明,水氟化可能弊大于利,导致犹他州等一些州撤销了氟化授权。本文旨在通过重新审视氟化物的益处、争议和潜在风险,提供一个关于氟化物的当代视角。它强调了氟化物在个人口腔护理和公共卫生中的双重作用,并强调了制定安全、公平和有效的输送策略以满足不同人群需求的必要性,平衡其预防优势与潜在健康问题。综述最后总结了国际牙科联合会关于通过全身和局部氟化促进口腔健康的政策声明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/12141933/23a165482936/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/12141933/b0bfae9678d9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/12141933/0a32d245132d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/12141933/23a165482936/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/12141933/b0bfae9678d9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/12141933/0a32d245132d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e43/12141933/23a165482936/gr3.jpg

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本文引用的文献

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Bangkok Declaration on Oral Health: A Clarion Call for Action by All Stakeholders.《曼谷口腔健康宣言:向所有利益相关者发出的行动号角》
Int Dent J. 2025 Apr;75(2):381-382. doi: 10.1016/j.identj.2025.03.003. Epub 2025 Mar 12.
2
The Transformative Role of Artificial Intelligence in Dentistry: A Comprehensive Overview. Part 1: Fundamentals of AI, and its Contemporary Applications in Dentistry.人工智能在牙科领域的变革性作用:全面概述。第1部分:人工智能基础及其在牙科领域的当代应用。
Int Dent J. 2025 Apr;75(2):383-396. doi: 10.1016/j.identj.2025.02.005. Epub 2025 Mar 11.
3
Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021.
1990年至2021年全球、区域和国家口腔疾病负担趋势:全球疾病负担研究2021的系统分析
Lancet. 2025 Mar 15;405(10482):897-910. doi: 10.1016/S0140-6736(24)02811-3. Epub 2025 Feb 27.
4
The Transformative Role of Artificial Intelligence in Dentistry: A Comprehensive Overview Part 2: The Promise and Perils, and the International Dental Federation Communique.人工智能在牙科领域的变革性作用:全面概述 第2部分:前景与风险,以及国际牙科联合会公报
Int Dent J. 2025 Apr;75(2):397-404. doi: 10.1016/j.identj.2025.02.006. Epub 2025 Feb 25.
5
Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis.氟暴露与儿童智商分数:一项系统评价与荟萃分析
JAMA Pediatr. 2025 Mar 1;179(3):282-292. doi: 10.1001/jamapediatrics.2024.5542.
6
The Remineralization of Enamel from Saliva: A Chemical Perspective.唾液对牙釉质的再矿化:化学视角
Dent J (Basel). 2024 Oct 23;12(11):339. doi: 10.3390/dj12110339.
7
Courting water fluoridation.倡导水氟化
J Am Dent Assoc. 2024 Dec;155(12):993-994. doi: 10.1016/j.adaj.2024.10.003. Epub 2024 Oct 30.
8
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PLoS One. 2024 Sep 30;19(9):e0308656. doi: 10.1371/journal.pone.0308656. eCollection 2024.
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Isr J Health Policy Res. 2024 Sep 20;13(1):50. doi: 10.1186/s13584-024-00637-5.
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NTP Monogr. 2024 Aug(8). doi: 10.22427/NTP-MGRAPH-8.