Shimozono Koutatsu, Adachi Hisashi, Nohara Shoichiro, Shibata Tatsuhiro, Sugiyama Yoichi, Ioji Tetsuya, Fukumoto Yoshihiro
Shimamatsu Cardiovascular Medicine Clinic, Fukuoka, Japan.
Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, 830-0011, Japan.
Sci Rep. 2025 May 13;15(1):16521. doi: 10.1038/s41598-025-99064-y.
Sleep-disordered breathing (SDB) links to various cardiovascular diseases (CVDs), but comprehensive insights and detailed profiles remain scarce. This study examined the clinical characteristics of CVD patients complicated by SDB in the enrolled all consecutive 5765 patients who underwent screening tests for SDB during hospitalization from January 2014 to December 2019, using the database of Cardiovascular Medicine, Kurume University Hospital. Desaturation during sleep in SDB was significantly worse in terms of age, sex, daytime resting oxygen saturation (SpO), systolic blood pressure (SBP), pulse pressure, body mass index (BMI), white blood cell count, hemoglobin A1c, serum creatinine, N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiothoracic ratio on chest X-ray, and left ventricular ejection fraction on echocardiography (all p-values < 0.001, except for SBP p = 0.002, and NT-proBNP p = 0.004). Coronary artery disease and heart failure, but not pulmonary hypertension, were associated with a higher prevalence and a greater risk of moderate to severe SDB, typically in older patients. Notably, low SpO during daytime and elevated BMI were indicative of SDB across all age categories for both sexes. Heatmaps of daytime SpO and BMI can effectively predict the severe SDB in patients with CVDs, suggesting the potential for efficient therapeutic interventions for SDB.
睡眠呼吸障碍（SDB）与多种心血管疾病（CVD）相关，但全面的见解和详细的概况仍然匮乏。本研究利用久留米大学医院心血管医学数据库，对2014年1月至2019年12月期间住院时接受SDB筛查测试的所有连续5765例患者中合并SDB的CVD患者的临床特征进行了研究。在年龄、性别、日间静息氧饱和度（SpO）、收缩压（SBP）、脉压、体重指数（BMI）、白细胞计数、糖化血红蛋白A1c、血清肌酐、N末端B型利钠肽原（NT-proBNP）、胸部X线心胸比以及超声心动图左心室射血分数方面，SDB患者睡眠期间的血氧饱和度下降情况显著更差（除SBP的p值为0.002，NT-proBNP的p值为0.004外，所有p值均<0.001）。冠状动脉疾病和心力衰竭，而非肺动脉高压，与中度至重度SDB的较高患病率和更大风险相关，这通常发生在老年患者中。值得注意的是，日间低SpO和升高的BMI表明所有年龄段的男女患者均存在SDB。日间SpO和BMI的热图可有效预测CVD患者的严重SDB，提示对SDB进行有效治疗干预的可能性。
