Zhang Dongming, Li Tianyu, Chen Bo, Margonis Georgios Antonios, Wang Jaeyun Jane, Han Jiashu, Ma Kaiqi, Chaomu Rilige, Lin Chen, Wang Weibin
Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100023, Beijing, People's Republic of China.
Department of General Surgery, Baotou Central Hospital, Baotou, 014040, Inner Mongolia, People's Republic of China.
Discov Oncol. 2025 May 14;16(1):758. doi: 10.1007/s12672-025-02504-4.
To report on cases of primary pancreatic signet ring cell carcinoma (PSRCC) from our institution, review the published literature, and evaluate the clinicopathological characteristics.
We present a recent case of PSRCC and report 11 additional cases from China, utilizing the China National Knowledge Infrastructure (CNKI) database. The literature search encompassed publications from January 1994 to December 2023. We also performed a literature search using PubMed and Web of Science to identify cases of PSRCC outside of China and identified a total of 13 additional cases.
A total of 12 cases from China were identified, with a mean age of 64 years. Among these, 11 patients (91.7%) were male, and 1 patient (8.3%) was female. The tumor was primarily located in the pancreatic head (7 cases, 57.3%), followed by the pancreatic body (3 cases, 25.0%) and tail (2 cases, 16.7%). Six patients (50%) underwent radical curative surgery, while the remaining 6 (50%) received palliative surgical treatment or chemotherapy. In the radical curative surgery group (6 patients), the longest follow-up was 23 months, with only one death reported. In contrast, all patients who received palliative treatment (6 patients) experienced short-term mortality, with the longest follow-up period being 5 months. While most patients were Chinese, similar outcomes have been reported in non-Chinese populations, indicating broader applicability.
PSRCC is a highly aggressive and extremely rare pancreatic malignancy, typically originating in the head of the pancreas. Patients diagnosed at an early stage and who undergo radical surgery demonstrate significantly prolonged survival.
报告我院原发性胰腺印戒细胞癌（PSRCC）病例，回顾已发表文献，并评估其临床病理特征。
我们介绍了一例近期的PSRCC病例，并利用中国知网（CNKI）数据库报告了另外11例来自中国的病例。文献检索涵盖了1994年1月至2023年12月的出版物。我们还使用PubMed和Web of Science进行文献检索，以确定中国以外的PSRCC病例，共确定了另外13例。
共确定了12例来自中国的病例，平均年龄为64岁。其中，11例患者（91.7%）为男性，1例患者（8.3%）为女性。肿瘤主要位于胰头（7例，57.3%），其次是胰体（3例，25.0%）和胰尾（2例，16.7%）。6例患者（50%）接受了根治性手术，其余6例（50%）接受了姑息性手术治疗或化疗。在根治性手术组（6例患者）中，最长随访时间为23个月，仅报告1例死亡。相比之下，所有接受姑息治疗的患者（6例）均出现短期死亡，最长随访期为5个月。虽然大多数患者为中国人，但非中国人群也报告了类似的结果，表明其适用性更广泛。
PSRCC是一种侵袭性很强且极为罕见的胰腺恶性肿瘤，通常起源于胰头。早期诊断并接受根治性手术的患者生存期显著延长。
