de Souto Barreto Philipe, Lu Wan-Hsuan, Tavassoli Neda, Nourhashémi Fatemeh, Gorga Bandeira de Mello Renato, Ferriolli Eduardo, Guyonnet Sophie, Rolland Yves, Soto Martín Maria Eugenia, Vellas Bruno
IHU HealthAge, Toulouse, France.
CERPOP UMR 1295, University of Toulouse III, INSERM, UPS, Toulouse, France.
Nat Aging. 2025 May 13. doi: 10.1038/s43587-025-00861-x.
Intrinsic capacity (IC) refers to physical and mental capacities that determine healthy aging. IC is the central element of the World Health Organization care pathway 'Integrated Care for Older People' (ICOPE). However, the operationalization of a composite IC measurement in clinical settings remains to be defined. We used screening data from ICOPE implementation in a real-life population of 27,706 adults 60 years or older that were users of primary care services to elaborate and cross-validate IC scores and centile values for men and women. Here, we show that IC centiles were cross-sectionally associated with comorbidity, frailty and limitations in both activities of daily living and instrumental activities of daily living. External validation using populations from high-income (French INSPIRE-T cohort) and upper-middle-income (ICOPE Brazil) countries validated the associations between IC centiles and clinical outcomes. The IC centiles developed using ICOPE screening data constitute a standardized parameter to monitor individual and population IC through a clinically friendly approach.
内在能力（IC）指的是决定健康老龄化的身体和心理能力。IC是世界卫生组织“老年人综合照护”（ICOPE）护理路径的核心要素。然而，复合IC测量在临床环境中的操作化定义仍有待确定。我们使用了ICOPE在27706名60岁及以上使用初级保健服务的成年人的真实人群中实施情况的筛查数据，来详细阐述并交叉验证男性和女性的IC分数及百分位数。在此，我们表明IC百分位数与共病、衰弱以及日常生活活动和工具性日常生活活动的受限呈横断面关联。使用来自高收入国家（法国INSPIRE-T队列）和中高收入国家（ICOPE巴西）人群进行的外部验证证实了IC百分位数与临床结局之间的关联。利用ICOPE筛查数据得出的IC百分位数构成了一个标准化参数，可通过临床友好的方法来监测个体和人群的IC。
