Puche-Juarez Maria, Toledano Juan M, Hinojosa-Nogueira Daniel, de Paco Matallana Catalina, Sánchez-Romero Javier, Ochoa Julio J, Carrillo Maria Paz, Martín-Álvarez Estefanía, Diaz-Castro Javier, Moreno-Fernandez Jorge
Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain.
Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Centre, University of Granada, 18016 Armilla, Spain.
Nutrients. 2025 Jan 17;17(2):321. doi: 10.3390/nu17020321.
Maternal nutrition during pregnancy plays a pivotal role in influencing both maternal and fetal health, impacting neonatal anthropometric outcomes and long-term disease susceptibility. An advanced maternal age (AMA ≥ 35 years) has been linked to increased risks of obstetric complications and adverse neonatal outcomes, yet its specific nutritional profile remains underexplored. : This study aimed to evaluate the nutrient and polyphenol intakes of women at an AMA compared to those of a younger control group and to investigate associations with neonatal anthropometric measures. : A cohort of 200 pregnant women, stratified into AMA and control groups, completed a food frequency questionnaire during the second trimester. Neonatal anthropometric data were collected at delivery. : Intakes of fiber, zinc, copper, selenium, vitamins E, B1, B3 and folate were lower in the AMA group in comparison with the control values. Negative correlations were found between fiber, vitamin A and vitamin E and the head circumference of the newborn, with fiber being identified as a potential predictor of this parameter. : Despite some limitations, such as the fact that the FFQ was completed only once during pregnancy and the cross-sectional design of the study, the findings highlight notable nutritional deficiencies among AMA women, which may influence neonatal outcomes such as head circumference. These results underscore the need for nutritional guidelines and supplementation strategies tailored to pregnant women over 35 years of age.
孕期的母体营养在影响母体和胎儿健康、新生儿人体测量结果及长期疾病易感性方面起着关键作用。高龄产妇（AMA≥35岁）与产科并发症风险增加及不良新生儿结局相关，但其具体营养状况仍未得到充分研究。本研究旨在评估高龄产妇与年轻对照组女性的营养素和多酚摄入量，并调查其与新生儿人体测量指标的关联。200名孕妇被分为高龄产妇组和对照组，在孕中期完成了一份食物频率问卷。分娩时收集新生儿人体测量数据。与对照组相比，高龄产妇组的纤维、锌、铜、硒、维生素E、B1、B3和叶酸摄入量较低。发现纤维、维生素A和维生素E与新生儿头围呈负相关，纤维被确定为该参数的潜在预测指标。尽管存在一些局限性，如孕期仅完成一次食物频率问卷且研究为横断面设计，但研究结果突出了高龄产妇存在显著的营养缺乏，这可能会影响新生儿头围等结局。这些结果强调了针对35岁以上孕妇制定营养指南和补充策略的必要性。
