局部晚期或转移性非透明细胞肾细胞癌的全身治疗
Systemic Treatment of Locally Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma.
作者信息
Vento Joseph, Zhang Tian, Kapur Payal, Hammers Hans, Brugarolas James, Qin Qian
机构信息
Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX 75235, USA.
Department of Pathology, University of Texas Southwestern, Dallas, TX 75235, USA.
出版信息
Cancers (Basel). 2025 Apr 30;17(9):1527. doi: 10.3390/cancers17091527.
Non-clear cell renal cell carcinoma (nccRCC) represents a heterogenous group of malignancies with varying degrees of clinical aggressiveness and response to different systemic therapies. As the characterization of subtypes of nccRCC continues to evolve, it is important to understand the evidence around systemic treatments used in advanced or metastatic stages of specific subtypes. Here, we review the literature on systemic therapies in nccRCC, with a focus on prospective trials that included patients with papillary renal cell carcinoma (RCC), chromophobe RCC, RCC not further classified/unclassified RCC, translocation RCC, collecting duct RCC, and renal medullary carcinoma. We also review emerging treatments for other molecularly defined subtypes of this disease.
非透明细胞肾细胞癌（nccRCC）是一组异质性恶性肿瘤，具有不同程度的临床侵袭性以及对不同全身治疗的反应。随着nccRCC亚型特征的不断演变，了解特定亚型晚期或转移性阶段使用的全身治疗的相关证据很重要。在此，我们回顾了nccRCC全身治疗的文献，重点关注纳入乳头状肾细胞癌（RCC）、嫌色细胞性RCC、未进一步分类/未分类RCC、易位性RCC、集合管RCC和肾髓质癌患者的前瞻性试验。我们还回顾了该疾病其他分子定义亚型的新兴治疗方法。
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