He Ying, Yang Hao, Liu Yaxin, Sun Yanting, Feng Zeguo, Zheng Xueying, Wang Fei, Ma Lei, Zhang Jianbao, Xu Dan, Guo Hui, Qin Liguo, Zhang Yali
Center for Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System, Institute of Design Science and Basic Components, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Foods. 2025 Apr 27;14(9):1536. doi: 10.3390/foods14091536.
is commonly utilized as a functional food in China and other Asian countries. The peach-shaped phase of this fungus is nutritionally and taste-wise similar to its mature fruiting bodies. However, there is limited research on the polysaccharides found in the peach-shaped . A heteropolysaccharide was extracted from the volva of peach-shaped (DIVP). Analyses using high-performance gel permeation chromatography, methylation and NMR revealed that DIVP comprises glucose, glucuronic acid, galactose, and mannose. Its structure features a backbone that consists of →3)-β-D-Glc-(1→ units with branches at →4)-β-D-Glc-(1→, →6)-α-D-Gal-(1→ and terminal α-Man-(1→ residues. Physicochemical assessments including X-ray diffraction, thermal, zeta potential and viscosity characterization indicated that DIVP is a semi-crystalline polymer exhibiting excellent physical and thermal stability. Cytokine antibody array and proteome profiler human phosphokinase analyses demonstrated that DIVP downregulates the expression levels of cytokines and alters the phosphorylation status of 16 proteins in human U937 macrophages induced by lipopolysaccharides, indicating its anti-inflammatory activity. These findings suggest that the polysaccharide from the volva of peach-shaped is primarily composed of β-1,3-glucan, which exhibits stable physicochemical properties and anti-inflammatory activity, providing a foundation for its potential use as an anti-inflammatory agent or functional food.
在中国和其他亚洲国家，它通常被用作功能性食品。这种真菌的桃形阶段在营养和口感上与其成熟的子实体相似。然而，关于桃形阶段中发现的多糖的研究有限。从桃形菌托中提取了一种杂多糖（DIVP）。使用高效凝胶渗透色谱、甲基化和核磁共振分析表明，DIVP由葡萄糖、葡萄糖醛酸、半乳糖和甘露糖组成。其结构特征是主链由→3)-β-D-葡萄糖-(1→单元组成，在→4)-β-D-葡萄糖-(1→、→6)-α-D-半乳糖-(1→和末端α-甘露糖-(1→残基处有分支。包括X射线衍射、热分析、zeta电位和粘度表征在内的物理化学评估表明，DIVP是一种半结晶聚合物，具有优异的物理和热稳定性。细胞因子抗体阵列和蛋白质组分析人磷酸激酶分析表明，DIVP下调细胞因子的表达水平，并改变脂多糖诱导的人U937巨噬细胞中16种蛋白质的磷酸化状态，表明其具有抗炎活性。这些发现表明，桃形菌托中的多糖主要由β-1,3-葡聚糖组成，具有稳定的物理化学性质和抗炎活性，为其作为抗炎剂或功能性食品的潜在用途提供了基础。
