De Oliveira Ana Paula Luiz, Lima Bruna Bressianini, Ramos Denise Jaques, Evangelista Gabriela Castro Lopes, Da Cruz Igor Cezar Kniphoff, Uscategui Ricardo Andrés Ramirez, de Nardi Andrigo Barboza, Feliciano Marcus Antônio Rossi
Departamento de Clínica e Cirurgia Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal 14884-900, SP, Brazil.
Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga 13635-900, SP, Brazil.
Animals (Basel). 2025 Apr 26;15(9):1223. doi: 10.3390/ani15091223.
Bladder tumors in dogs represent approximately 2% of all malignant lesions recorded, with urothelial carcinoma being the most common and aggressive form. This study aimed to characterize the elastographic properties of canine urothelial carcinoma using ARFI (Acoustic Radiation Force Impulse) elastography and to evaluate its diagnostic capacity. Seven dogs with urothelial carcinoma and nine healthy dogs were evaluated, comparing shear wave velocity (SWV) and bladder wall thickness between the groups. The results showed that SWV was significantly higher in dogs with urothelial carcinoma (median of 2.53 m/s) compared with healthy dogs (median of 1.41 m/s) ( = 0.0045). Bladder wall thickness was also greater in dogs with carcinoma (0.28 ± 0.05 cm) compared to healthy dogs (0.14 ± 0.26 cm) ( = 0.0003). Receiver operating characteristic (ROC) curve analysis revealed a high sensitivity (100%) and specificity (88.9%) for SWV in differentiating healthy and neoplastic tissues. These findings suggest that ARFI elastography is a promising tool for diagnosing urothelial carcinoma in dogs, offering a noninvasive and quantitative approach that can complement traditional diagnostic methods. ARFI elastography may aid in early diagnosis and clinical management, improving the prognosis of patients with bladder neoplasia.
犬膀胱肿瘤约占所有记录的恶性病变的2%，其中尿路上皮癌是最常见且侵袭性最强的类型。本研究旨在利用ARFI（声辐射力脉冲）弹性成像技术对犬尿路上皮癌的弹性成像特性进行表征，并评估其诊断能力。对7只患有尿路上皮癌的犬和9只健康犬进行了评估，比较了两组之间的剪切波速度（SWV）和膀胱壁厚度。结果显示，与健康犬（中位数为1.41 m/s）相比，患有尿路上皮癌的犬的SWV显著更高（中位数为2.53 m/s）（ = 0.0045）。患有癌症的犬的膀胱壁厚度（0.28±0.05 cm）也比健康犬（0.14±0.26 cm）更大（ = 0.0003）。受试者操作特征（ROC）曲线分析显示，SWV在区分健康组织和肿瘤组织方面具有较高的敏感性（100%）和特异性（88.9%）。这些发现表明，ARFI弹性成像技术是诊断犬尿路上皮癌的一种有前景的工具，提供了一种非侵入性的定量方法，可以补充传统诊断方法。ARFI弹性成像技术可能有助于早期诊断和临床管理，改善膀胱肿瘤患者的预后。
