Yoǧurtçuoǧlu Burak, Damar Çaǧrı
Department of Radiology, Faculty of Medicine, Gaziantep University, Üniversite Bulvarı, Șehitkamil, Turkey.
Ultrasonography. 2021 Oct;40(4):575-583. doi: 10.14366/usg.20173. Epub 2021 Mar 4.
The aim of this study was to compare the acoustic radiation force impulse elastography (ARFI-e) values of the renal cortical parenchyma in children with acute glomerulonephritis (AGN) and healthy children, and to determine a cut-off point for the diagnosis of AGN.
This prospective study included 30 children with biopsy-proven AGN and 30 healthy children. All the children underwent renal ARFI-e measurements. Values were obtained from the upper, middle, and lower zones of the right kidney parenchyma. A total of nine ARFI-e measurements (three from each zone) were made. Statistical analyses were conducted of the mean elastography values (MEVs) of the children in both groups.
In the patient group, the MEVs measured from the upper, middle and lower zones of the right kidney were 3.42±0.42 m/s, 3.45±0.45 m/s, and 3.39±0.39 m/s (average, 3.42±0.34 m/s), respectively. In the healthy control group, the MEVs measured from the upper, middle, and lower zones of the right kidney were 2.85±0.63 m/s, 2.85±0.68 m/s, and 2.86±0.66 m/s (average, 2.85±0.57 m/s), respectively. The MEVs in all zones were significantly higher in the patient group than in the healthy group (P<0.001). The cut-off values determined to predict AGN in the upper, middle, and lower zones of the kidney were 2.74 m/s (sensitivity, 96.67%; specificity, 46.67%), 2.71 m/s (sensitivity, 96.67%; specificity, 53.33%), and 2.81 m/s (sensitivity, 93.33%; specificity, 56.67%), respectively.
The ARFI-e technique can be considered as a non-invasive, easily applicable, auxiliary method for the early diagnosis of AGN.
本研究旨在比较急性肾小球肾炎（AGN）患儿与健康儿童肾皮质实质的声辐射力脉冲弹性成像（ARFI-e）值，并确定AGN诊断的截断点。
本前瞻性研究纳入30例经活检证实的AGN患儿和30例健康儿童。所有儿童均接受肾脏ARFI-e测量。从右肾实质的上、中、下区域获取数值。共进行9次ARFI-e测量（每个区域3次）。对两组儿童的平均弹性成像值（MEV）进行统计分析。
患者组中，右肾上、中、下区域测量的MEV分别为3.42±0.42 m/s、3.45±0.45 m/s和3.39±0.39 m/s（平均，3.42±0.34 m/s）。在健康对照组中，右肾上、中、下区域测量的MEV分别为2.85±0.63 m/s、2.85±0.68 m/s和2.86±0.66 m/s（平均，2.85±0.57 m/s）。患者组所有区域的MEV均显著高于健康组（P<0.001）。预测肾脏上、中、下区域AGN的截断值分别为2.74 m/s（敏感性，96.67%；特异性，46.67%）、2.71 m/s（敏感性，96.67%；特异性，53.33%）和2.81 m/s（敏感性，93.33%；特异性，56.67%）。
ARFI-e技术可被视为一种用于AGN早期诊断的非侵入性、易于应用的辅助方法。
