Hongwei Li, Zhenhai Shen, Wei Jiang, Bing Jia, Shaolei Li, Ping Zhang, Liuyu Wang, Peng Yuan, Yun Lu
Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, Wuxi, 214023, China.
Department of Cardiovascular Medicine, Jiangsu Provincial People's Hospital Group Taihu Sanatorium of Jiangsu Province, Wuxi, 214086, China.
Sci Rep. 2025 Jan 6;15(1):956. doi: 10.1038/s41598-024-84617-4.
Novel anthropometric indices are more closely related to metabolic abnormalities than traditional anthropometric indices. Fewer studies have been conducted based on the relationship between novel anthropometric indicators and hyperuricemia. This study was to analyze the serum uric acid (SUA) levels of adults and the relationship between hyperuricemia and these new indicators in Su-Wuxi-Chang area of China, in order to provide a theoretical basis for the management of SUA levels in patients with hyperuricemia. A total of 14,834 adults were enrolled. The information of height, weight, waist circumference, lifestyle, fasting plasma glucose (FPG), lipids, and SUA were collected. The traditional obesity indices and novel anthropometric indices were calculated by formulas. Lipid accumulation product (LAP), triglyceride glucose (TyG) and body roundness index (BRI) are independent risk factors for hyperuricemia in both men and women (P < 0.001). In males, the predictive ability of LAP and TyG to the incidence of hyperuricemia were 0.694 and 0.661 in AUC area, respectively (P < 0.001) and which were 0.767 and 0.746 respectively in females (P < 0.001). In both men and women, the LAP and TyG indices were more predictive of hyperuricemia than the other indices (P < 0.001). The capacity of LAP and TyG indexes were better than other traditional anthropometric indexes in predicting hyperuricemia in this population. The predicted hyperuricemia ablity of LAP in both male and female better than other traditional and new anthropometric indicators.
新型人体测量指标比传统人体测量指标与代谢异常的关系更为密切。基于新型人体测量指标与高尿酸血症之间的关系所开展的研究较少。本研究旨在分析中国苏锡常地区成年人的血清尿酸（SUA）水平以及高尿酸血症与这些新指标之间的关系，以便为高尿酸血症患者的SUA水平管理提供理论依据。共纳入14834名成年人。收集了身高、体重、腰围、生活方式、空腹血糖（FPG）、血脂和SUA的信息。通过公式计算传统肥胖指标和新型人体测量指标。脂质蓄积产物（LAP）、甘油三酯葡萄糖（TyG）和身体圆润度指数（BRI）是男性和女性高尿酸血症的独立危险因素（P<0.001）。在男性中，LAP和TyG对高尿酸血症发生率的预测能力在AUC面积中分别为0.694和0.661（P<0.001），在女性中分别为0.767和0.746（P<0.001）。在男性和女性中，LAP和TyG指数对高尿酸血症的预测性均高于其他指数（P<0.001）。在该人群中，LAP和TyG指数预测高尿酸血症的能力优于其他传统人体测量指标。LAP在男性和女性中预测高尿酸血症的能力均优于其他传统和新型人体测量指标。
