Mutailipu Kelibinuer, Du Lei, Guo Junwei, Liu Shuwei, Chen Yue, Lu Liesheng, Qu Shen, Chen Haibing, Bu Le
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Institute of Obesity, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Department of Metabolic Surgery, Shanghai Tenth People's Hospital, Institute of Obesity, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Dec 9;17:4721-4733. doi: 10.2147/DMSO.S483638. eCollection 2024.
This study aimed to investigate the association of the triglyceride-glucose index (TyG) and its related parameters with the risk of hyperuricemia in patients with obesity of different sexes.
In this cross-sectional study, a total of 951 patients with obesity were included. They were divided into two groups based on their serum uric acid levels, and separate analyses were conducted for males and females. Binary logistic regression analysis using the backward likelihood ratio (LR) approach was performed to investigate the association between hyperuricemia and indicators related to obesity and lipids.
Multivariate logistic regression analysis indicated that, across the overall population, higher quartiles of the TyG and TyG-BMI indexes were significantly associated with an increased risk of hyperuricemia (HUA) after adjusting for confounding factors. Specifically, in the fourth quartile of the TyG index, the odds ratio (OR) for HUA was 3.16 (95% confidence interval [CI]: 1.39-7.18), and for the TyG-BMI index, the OR was 4.06 (95% CI: 1.73-9.52) in the fully adjusted model. In sex-specific analyses, for males, those in the third quartile of the TyG-WC index had a higher likelihood of HUA (OR, 8.13; 95% CI, 2.28-29.01) compared to the lowest quartile. Among females, an elevated TyG index was significantly associated with increased HUA risk, with an OR of 5.13 (95% CI: 1.66-15.92) in the fourth quartile.
Sex-based differences exist regarding the risk factors for hyperuricemia in patients with obesity. An elevated TyG-WC index is linked to an increased risk in males, while an elevated TyG index is associated with an increased risk in females.
本研究旨在探讨甘油三酯-葡萄糖指数（TyG）及其相关参数与不同性别肥胖患者高尿酸血症风险的关联。
在这项横断面研究中，共纳入951例肥胖患者。根据血清尿酸水平将他们分为两组，并对男性和女性分别进行分析。采用向后似然比（LR）法进行二元逻辑回归分析，以研究高尿酸血症与肥胖和血脂相关指标之间的关联。
多因素逻辑回归分析表明，在总体人群中，校正混杂因素后，TyG和TyG-BMI指数的较高四分位数与高尿酸血症（HUA）风险增加显著相关。具体而言，在TyG指数的第四个四分位数中，完全调整模型中HUA的优势比（OR）为3.16（95%置信区间[CI]：1.39 - 7.18），TyG-BMI指数的OR为4.06（95%CI：1.73 - 9.52）。在性别特异性分析中，对于男性，TyG-WC指数第三个四分位数的患者发生HUA的可能性高于最低四分位数（OR，8.13；95%CI，2.28 - 29.01）。在女性中，TyG指数升高与HUA风险增加显著相关，在第四个四分位数中OR为5.13（95%CI：1.66 - 15.92）。
肥胖患者高尿酸血症的危险因素存在性别差异。TyG-WC指数升高与男性风险增加相关，而TyG指数升高与女性风险增加相关。
