Wang James Jia-Dong, Quak Glenys Shu-Wei, Lee Hui-Bing, Foo Li-Xin, Tay Phoebe, Mah Shi-Min, Tong Cherie, Koh Frederick Hong-Xiang
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 639798, Singapore.
Department of Dietetics, Sengkang General Hospital, Singapore 544886, Singapore.
Nutrients. 2025 Apr 29;17(9):1512. doi: 10.3390/nu17091512.
: Vitamin D is vital for musculoskeletal health, with emerging evidence highlighting its role in muscle function. While its preoperative and postoperative benefits for bone health are well documented, the effect of vitamin D supplementation on post-surgical muscle recovery remains underexplored. This systematic review consolidates current evidence on the impact of vitamin D supplementation in enhancing muscle strength following surgery. : This review adhered to PRISMA guidelines and was registered on PROSPERO. A systematic search of PubMed, EMBASE, and Cochrane databases was conducted, covering articles from inception to 15 January 2025. Studies evaluating the effect of vitamin D supplementation on muscle strength in surgical contexts were included. Data extraction focused on study design, population demographics, vitamin D dosage, timing, and measured outcomes. A narrative synthesis was performed due to heterogeneity in study designs and outcomes. : From 701 initial records, 10 studies met the inclusion criteria. The findings indicate that vitamin D supplementation, particularly high-dose regimens administered preoperatively or early postoperatively, significantly improves muscle strength and functional outcomes in orthopaedic surgeries, such as hip and knee replacements, and bariatric surgeries. The benefits varied by surgical type, baseline vitamin D levels, and supplementation strategy. However, inconsistent dosing regimens and limited long-term follow-up studies hinder conclusive evidence. : Vitamin D supplementation demonstrates potential in enhancing post-surgical muscle recovery and functional outcomes. Tailored supplementation strategies, based on patient-specific needs and surgical context, are essential. Future research should address optimal dosing regimens and evaluate long-term impacts on recovery and quality of life.
维生素D对肌肉骨骼健康至关重要，新出现的证据凸显了其在肌肉功能中的作用。虽然其术前和术后对骨骼健康的益处已有充分记录，但维生素D补充剂对术后肌肉恢复的影响仍未得到充分探索。本系统评价整合了当前关于维生素D补充剂对术后增强肌肉力量影响的证据。
本评价遵循PRISMA指南，并在PROSPERO上注册。对PubMed、EMBASE和Cochrane数据库进行了系统检索，涵盖从创刊到2025年1月15日的文章。纳入评估维生素D补充剂在手术环境中对肌肉力量影响的研究。数据提取集中在研究设计、人群统计学、维生素D剂量、时间和测量结果。由于研究设计和结果存在异质性，进行了叙述性综合分析。
从701条初始记录中，有10项研究符合纳入标准。研究结果表明，补充维生素D，尤其是术前或术后早期给予的高剂量方案，能显著改善骨科手术（如髋关节和膝关节置换术）和减肥手术中的肌肉力量和功能结果。益处因手术类型、基线维生素D水平和补充策略而异。然而，给药方案不一致以及长期随访研究有限阻碍了确凿证据的得出。
补充维生素D在增强术后肌肉恢复和功能结果方面显示出潜力。根据患者的具体需求和手术情况制定个性化的补充策略至关重要。未来的研究应确定最佳给药方案，并评估对恢复和生活质量的长期影响。
