Centre for Diabetes, Obesity and Endocrinology (CDOE), The Westmead Institute for Medical Research, The University of Sydney, Sydney 2145, Australia.
Faculty of Medicine and Health, The University of Sydney, Sydney 2145, Australia.
Nutrients. 2023 Oct 16;15(20):4377. doi: 10.3390/nu15204377.
Vitamin D deficiency, prevalent worldwide, is linked to muscle weakness, sarcopenia, and falls. Muscle regeneration is a vital process that allows for skeletal muscle tissue maintenance and repair after injury. PubMed and Web of Science were used to search for studies published prior to May 2023. We assessed eligible studies that discussed the relationship between vitamin D, muscle regeneration in this review. Overall, the literature reports strong associations between vitamin D and skeletal myocyte size, and muscle regeneration. In vitro studies in skeletal muscle cells derived from mice and humans showed vitamin D played a role in regulating myoblast growth, size, and gene expression. Animal studies, primarily in mice, demonstrate vitamin D's positive effects on skeletal muscle function, such as improved grip strength and endurance. These studies encompass vitamin D diet research, genetically modified models, and disease-related mouse models. Relatively few studies looked at muscle function after injury, but these also support a role for vitamin D in muscle recovery. The human studies have also reported that vitamin D deficiency decreases muscle grip strength and gait speed, especially in the elderly population. Finally, human studies reported the benefits of vitamin D supplementation and achieving optimal serum vitamin D levels in muscle recovery after eccentric exercise and surgery. However, there were no benefits in rotator cuff injury studies, suggesting that repair mechanisms for muscle/ligament tears may be less reliant on vitamin D. In summary, vitamin D plays a crucial role in skeletal muscle function, structural integrity, and regeneration, potentially offering therapeutic benefits to patients with musculoskeletal diseases and in post-operative recovery.
维生素 D 缺乏症在全球范围内普遍存在，与肌肉无力、肌肉减少症和跌倒有关。肌肉再生是一种至关重要的过程，可维持和修复损伤后的骨骼肌组织。使用 PubMed 和 Web of Science 搜索了截至 2023 年 5 月之前发表的研究。我们评估了讨论维生素 D 与肌肉再生之间关系的合格研究。总的来说，文献报告了维生素 D 与骨骼肌细胞大小和肌肉再生之间的强相关性。在源自小鼠和人类的骨骼肌细胞的体外研究中，维生素 D 在调节成肌细胞生长、大小和基因表达方面发挥作用。动物研究主要在小鼠中表明，维生素 D 对骨骼肌功能有积极影响，例如提高握力和耐力。这些研究涵盖了维生素 D 饮食研究、基因修饰模型和与疾病相关的小鼠模型。很少有研究关注损伤后的肌肉功能，但这些研究也支持维生素 D 在肌肉恢复中的作用。人类研究还报告称，维生素 D 缺乏会降低肌肉握力和步态速度，尤其是在老年人群中。最后，人类研究报告了维生素 D 补充和在离心运动和手术后达到最佳血清维生素 D 水平对肌肉恢复的益处。然而，在肩袖损伤研究中没有益处，这表明肌肉/韧带撕裂的修复机制可能较少依赖于维生素 D。总之，维生素 D 在骨骼肌功能、结构完整性和再生中起着至关重要的作用，可能为患有肌肉骨骼疾病和术后恢复的患者提供治疗益处。
