Andone Sebastian, Lénárd Farczádi, Imre Silvia, Dumitreasa Mihai, Bălașa Rodica
Ist Neurology Clinic, Emergency Clinical County Hospital Târgu Mureș, 540136 Târgu Mureș, Romania.
Department of Neurology, 'George Emil Palade' University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540136 Târgu Mureș, Romania.
Nutrients. 2025 Apr 30;17(9):1518. doi: 10.3390/nu17091518.
: This study aims to investigate the role of fatty acid ratios, specifically DHA/ARA and EPA/ARA, in predicting severe disability and mortality in stroke patients and compare these ratios with conventional risk factors such as age, sex, hypertension, diabetes, and dyslipidemia. : A prospective study was conducted involving 298 consecutive acute ischemic stroke patients (within 72 h of onset). Fatty acid ratios were measured from plasma, and all patients' evolution was followed through hospitalization. Binary logistic regression analysis was used to identify predictors of severe disability at discharge (Rankin 4-6) and in-hospital mortality, including fatty acid ratios and conventional risk factors. : A higher DHA/ARA ratio was associated with a reduced chance of severe disability (OR = 0.81), while a higher EPA/ARA ratio was associated with an increased chance of severe disability (OR = 1.70). Age was a significant factor, with older age (median 70 years) associated with a lower survivability chance (OR = 0.93) and a higher likelihood of severe disability when surviving. Fatty acid ratios did not significantly affect mortality outcomes. For male patients, EPA/AA ratios showed a powerful association with severe disability ( = 0.045), while no significant effect of fatty acids was observed in females. : Fatty acids were significant predictors of severe disability in patients with acute ischemic stroke, independent of conventional risk factors, but without having any effect on in-hospital mortality. Age remained the only significant conventional risk factor predictor of outcome. Integrating fatty acid ratios alongside conventional risk factors may improve predictions of severe post-stroke disability, potentially guiding more personalized interventions for stroke patients.
本研究旨在探讨脂肪酸比例，特别是DHA/ARA和EPA/ARA，在预测中风患者严重残疾和死亡率方面的作用，并将这些比例与年龄、性别、高血压、糖尿病和血脂异常等传统风险因素进行比较。
进行了一项前瞻性研究，纳入298例连续的急性缺血性中风患者（发病72小时内）。从血浆中测量脂肪酸比例，并跟踪所有患者的住院病情进展。采用二元逻辑回归分析来确定出院时严重残疾（Rankin 4 - 6级）和院内死亡率的预测因素，包括脂肪酸比例和传统风险因素。
较高的DHA/ARA比例与严重残疾几率降低相关（OR = 0.81），而较高的EPA/ARA比例与严重残疾几率增加相关（OR = 1.70）。年龄是一个重要因素，年龄较大（中位数70岁）与较低的生存几率（OR = 0.93）相关，且存活时严重残疾的可能性较高。脂肪酸比例对死亡率结果没有显著影响。对于男性患者，EPA/AA比例与严重残疾有很强的关联（P = 0.045），而在女性中未观察到脂肪酸的显著影响。
脂肪酸是急性缺血性中风患者严重残疾的重要预测因素，独立于传统风险因素，但对院内死亡率没有影响。年龄仍然是唯一对预后有显著影响的传统风险因素预测指标。将脂肪酸比例与传统风险因素结合起来，可能会改善对中风后严重残疾的预测，有可能为中风患者指导更个性化的干预措施。
