Bell Victoria, Dimitrov Palmen, Fernandes Tito
Faculty of Pharmacy, University of Coimbra, Polo das Ciências da Saúde, Azinhaga de Stª Comba, 3000-548 Coimbra, Portugal.
LAQV-REQUIMTE, Portuguese Research Centre for Sustainable Chemistry, Rua D. Manuel II, Apartado, 55142 Porto, Portugal.
Nutrients. 2025 May 2;17(9):1568. doi: 10.3390/nu17091568.
Due to the extensive types of etiologies and risks causing over 600 types of mental health issues, to convene adequate recommendations in primary care is a difficult assignment. The starting point for preventive interventions on neurologic disorders involves scrutinizing the risk factors while targeting multiple hazards in order to increase the success of an early precautionary mediation plan of action. The primary risk factor for most neurodegenerative diseases is the increasing worldwide median age, although one in seven youngsters also experience a mental disability, namely depression, representing a decline in well-being and conferring a considerable global public health challenge. The brain operates optimally when supported by a holistic approach engaging several aspects, and diet is becoming an integral part of care strategies. Treatment is presently dominated by pharmacotherapy, but additional strategies are needed to prevent and treat mental disorders. Dietary modification can prove to be a cost-effective strategy for the prevention and, in certain conditions, treatment of neurological disorders. Molecules of dietary ingredients, micronutrients, phytonutrients, and additives may modulate depression associated biomarkers. Nutritional exposure during the early developmental stages and maternal impact, lifestyles, and the modulation of the gut microbiota through diet as novel therapies for the treatment of various neuropsychiatric conditions is gaining interest for maintaining brain health. Bioactive substances present in different mushroom species have been ascribed to both direct and indirect mechanisms of influence on neurobehavior, and here we support the recognition of mushroom nutrition as an influential dietary element in prevention and management of some neurologic concerns. Scientific evidence demonstrating the unequivocal link between nutritional mushrooms and cognitive health is only beginning to emerge, and nutritional medicine should be considered as an integral part of mental care.
由于导致600多种心理健康问题的病因和风险类型广泛,在初级保健中提出充分的建议是一项艰巨的任务。神经系统疾病预防干预的起点是仔细审查风险因素,同时针对多种危害,以提高早期预防性调解行动计划的成功率。大多数神经退行性疾病的主要风险因素是全球年龄中位数的增加,尽管每七个年轻人中就有一个也患有精神残疾,即抑郁症,这代表着幸福感的下降,并带来了相当大的全球公共卫生挑战。当大脑得到涉及多个方面的整体方法的支持时,其运作最为理想,而饮食正成为护理策略的一个组成部分。目前治疗主要以药物治疗为主,但还需要其他策略来预防和治疗精神障碍。饮食调整可能被证明是预防以及在某些情况下治疗神经系统疾病的一种具有成本效益的策略。饮食成分、微量营养素、植物营养素和添加剂的分子可能调节与抑郁症相关的生物标志物。早期发育阶段的营养暴露以及母亲的影响、生活方式,以及通过饮食调节肠道微生物群作为治疗各种神经精神疾病的新疗法,正越来越受到人们的关注,以维护大脑健康。不同蘑菇种类中存在的生物活性物质已被归因于对神经行为的直接和间接影响机制,在这里我们支持将蘑菇营养视为预防和管理某些神经问题的一种有影响力的饮食元素。证明营养蘑菇与认知健康之间明确联系的科学证据才刚刚开始出现,营养医学应被视为精神护理的一个组成部分。