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基于多糖、蛋白质和脂质的递送系统在提高辣椒素生物利用度方面的应用与研究进展——综述

Recent Advances in the Applications and Studies of Polysaccharide-, Protein-, and Lipid-Based Delivery Systems in Enhancing the Bioavailability of Capsaicin-A Review.

作者信息

Qiu Xiang, Xie Jing, Mei Jun

机构信息

College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

National Experimental Teaching Demonstration Center for Food Science and Engineering, Shanghai Ocean University, Shanghai 201306, China.

出版信息

Polymers (Basel). 2025 Apr 27;17(9):1196. doi: 10.3390/polym17091196.

DOI:10.3390/polym17091196
PMID:40362978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12073809/
Abstract

The primary active ingredient in capsicum is capsaicin. However, capsaicin bioavailability is low due to its restricted water solubility, and its potent spicy flavor will further restrict its use in food. This paper provides a complete overview of capsaicin. The biological activity of capsaicin and its impacts on metabolism in vivo are described. To increase capsaicin stability and bioavailability, several capsaicin-based delivery systems, including liposomes, double emulsions, nanoparticle mesosystems, and multiple systems made of distinct hydrocolloids, are covered in this review. Finally, potential uses for food preservation are introduced in line with this. Numerous delivery systems introduced in this review have effectively solved the problems of poor water solubility and poor bioavailability of capsaicin. Although capsaicin has potential uses in food preservation, there is little research on its application in functional food development. More innovative capsaicin-based delivery methods should be established, and more capsaicin-based applications should be developed in the future.

摘要

辣椒中的主要活性成分是辣椒素。然而,由于其有限的水溶性,辣椒素的生物利用度较低,并且其强烈的辛辣味会进一步限制其在食品中的应用。本文对辣椒素进行了全面概述。描述了辣椒素的生物活性及其对体内代谢的影响。为了提高辣椒素的稳定性和生物利用度,本综述涵盖了几种基于辣椒素的递送系统,包括脂质体、双重乳液、纳米颗粒介观系统以及由不同水胶体制成的多重系统。最后,据此介绍了其在食品保鲜方面的潜在用途。本综述中介绍的众多递送系统有效地解决了辣椒素水溶性差和生物利用度低的问题。尽管辣椒素在食品保鲜方面有潜在用途,但其在功能性食品开发中的应用研究较少。未来应建立更多基于辣椒素的创新递送方法,并开发更多基于辣椒素的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/d16fe0f2e68c/polymers-17-01196-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/b5954ad0a92e/polymers-17-01196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/d84e7e7db9f5/polymers-17-01196-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/e3c8bee13da1/polymers-17-01196-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/4865dae1c322/polymers-17-01196-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/d16fe0f2e68c/polymers-17-01196-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/b5954ad0a92e/polymers-17-01196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/d84e7e7db9f5/polymers-17-01196-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/e3c8bee13da1/polymers-17-01196-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/4865dae1c322/polymers-17-01196-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be7/12073809/d16fe0f2e68c/polymers-17-01196-g005.jpg

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Nutrients. 2024 Nov 1;16(21):3758. doi: 10.3390/nu16213758.
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Evaluation of Cytotoxic and Anti-cancer Potential of Capsaicin on Lung Cancer Cell Line: An In Vitro Investigation.辣椒素对肺癌细胞系的细胞毒性和抗癌潜力评估:一项体外研究。
Cureus. 2024 Aug 29;16(8):e68119. doi: 10.7759/cureus.68119. eCollection 2024 Aug.
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Effect of Paprika Powder on the Antioxidant Capacity of Emulsion-Type Sausages.辣椒粉对乳化型香肠抗氧化能力的影响。
Food Sci Anim Resour. 2024 Sep;44(5):1126-1141. doi: 10.5851/kosfa.2024.e53. Epub 2024 Sep 1.
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Capsaicin Modulates Hepatic and Intestinal Inflammation and Oxidative Stress by Regulating the Colon Microbiota.辣椒素通过调节结肠微生物群来调节肝脏和肠道炎症及氧化应激。
Antioxidants (Basel). 2024 Aug 2;13(8):942. doi: 10.3390/antiox13080942.
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Development of a probiotic low-fat set yogurt containing concentrated sweet pepper extract.一种含有浓缩甜椒提取物的益生菌低脂凝固型酸奶的研制。
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