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恒河猴的主要组织相容性复合体,RhL - A。VII。五种新的血清学定义抗原的鉴定。

The major histocompatibility complex of rhesus monkeys, RhL--A. VII. Identification of five new serologically defined antigens.

作者信息

van Vreeswijk W, Roger J H, D'Amaro J, Balner H

出版信息

Tissue Antigens. 1977 Jan;9(1):17-30. doi: 10.1111/j.1399-0039.1977.tb01075.x.

Abstract

Five new serologically defined (SD) tissue antigens of rhesus monkeys are described. Results of a population study and a segregation analysis in families were consistent with their control by the major histocompatibility complex (MHC), as alleles of the two previously established SD loci of RhL--A. The number of identifiable SD specificities of the rhesus monkeys' MHC is now twenty-five, thirteen controlled by the SD1 locus and twelve by SD2. The recombination frequency between SD1 and SD2 is estimated to be 0.3%. No evidence of a third SD series, as analogue of the human HLA--C locus, has yet been found.

摘要

本文描述了恒河猴的五种新的血清学定义(SD)组织抗原。群体研究和家系分离分析的结果表明,它们受主要组织相容性复合体(MHC)控制,如同RhL-A的两个先前确定的SD位点的等位基因。恒河猴MHC可识别的SD特异性数量目前为25种,其中13种由SD1位点控制,12种由SD2位点控制。估计SD1和SD2之间的重组频率为0.3%。尚未发现作为人类HLA-C位点类似物的第三个SD系列的证据。

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