Al-Deerawi Zaid, El-Badawi Kamal, Shrivastava Arpan, Barrak Husham
Queen Elizabeth Hospital, Birmingham B15 2GW, UK.
Queen Elizabeth the Queen Mother Hospital, Margate, Kent CT9 4AN, UK.
J Clin Med. 2025 May 6;14(9):3208. doi: 10.3390/jcm14093208.
: Kuttner's tumour refers to chronic sclerosing sialadenitis commonly affecting the submandibular gland. It clinically mimics submandibular gland neoplasms and has a possible association with IgG4-related disease. The literature on standardised diagnostic and management pathways is limited. This paper presents a case series and narrative literature review to support a proposed diagnostic and management approach for Kuttner's tumour. : Twelve cases of patients with a Kuttner's tumour aged between 55 and 87, identified from 2018 to 2025 through hospital records, were reviewed. All patients underwent ultrasound assessment using standardised diagnostic criteria and were followed up clinically and radiologically every six months. In parallel, we performed a narrative review of studies published between 2005 and 2025, identifying nine relevant articles to contextualise our findings. : Our 12-patient case series highlights the potential for Kuttner's tumour to progress to bilateral involvement and IgG4-related disease. Most cases resolved spontaneously with ultrasound-led monitoring. One progressed to IgG4-RD and responded to glucocorticoids. Our findings support the selective use of invasive tests, baseline serum IgG4 testing, and a six-monthly follow-up strategy. Despite similarities within the existing literature, international variation highlights the need for standardised diagnostic and management protocols. : We recommend a conservative, structured approach to managing Kuttner's tumour, with six-monthly clinical and radiological follow-ups. Based on one case progressing to multi-organ IgG4-related disease, we now recommend routinely measuring serum IgG4 concentrations at diagnosis. The role of magnetic resonance imaging, fine-needle aspiration cytology, and biopsy should be considered on a case-by-case basis. Further research is needed to validate this approach and assess long-term outcomes.
库特纳瘤是指通常累及下颌下腺的慢性硬化性涎腺炎。其临床表现类似于下颌下腺肿瘤,可能与IgG4相关疾病有关。关于标准化诊断和管理途径的文献有限。本文通过病例系列和叙述性文献综述,以支持提出的库特纳瘤诊断和管理方法。
回顾了2018年至2025年通过医院记录确定的12例年龄在55至87岁之间的库特纳瘤患者。所有患者均按照标准化诊断标准接受超声评估,并每六个月进行临床和影像学随访。同时,我们对2005年至2025年发表的研究进行了叙述性综述,确定了9篇相关文章以阐述我们的研究结果。
我们的12例患者病例系列突出了库特纳瘤进展为双侧受累和IgG4相关疾病的可能性。大多数病例在超声引导监测下自发缓解。1例进展为IgG4相关性疾病并对糖皮质激素有反应。我们的研究结果支持选择性使用侵入性检查、基线血清IgG4检测和每六个月一次的随访策略。尽管现有文献存在相似之处,但国际差异凸显了标准化诊断和管理方案的必要性。
我们建议采用保守、结构化的方法来管理库特纳瘤,每六个月进行临床和影像学随访。基于1例进展为多器官IgG4相关疾病的病例,我们现在建议在诊断时常规测量血清IgG4浓度。磁共振成像、细针穿刺细胞学检查和活检的作用应根据具体情况考虑。需要进一步研究来验证这种方法并评估长期结果。